Human secreted LAG3, Fc fusion protein, also known as Lymphocyte-Activation Gene 3 and CD223. GenBank Accession No. NM_002286, a.a. 23-450 expressed in a HEK293 cell expression system. MW = 73.1 kDa (monomer). This protein runs at a higher MW by SDS-PAGE due to glycosylation.
Immunogen Region
23-450
Tag
C-terminal Fc fusion (Human IgG1)
Formulation
40 mM Tris, pH 8.0, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol.
Species
Human
Application
Useful for studying protein binding and screening small molecular inhibitors
Endotoxin Level
<1 EU/ug
Notes
The aggregation state of this product has been confirmed to be<10%. Avoid freeze/thaw cycles.
GenBank
NM_002286
Mw(kda)
73.1 kDa
Synonyms
Lymphocyte-Activation Gene 3, CD223, Lag, Lag-3
Uniprot
P18627
Shipping Temperature
-80°C (dry ice)
Format
Aqueous buffer solution
Storage
At least 6 months at -80°C.
Reference
1. Byrnes, et al. Cytometry A. 2012 Sep;81(2):165-8. 2. Di, Carlo., et al., J. Pathol. 2005 Jan; 205(1):82-91.