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Home / Proteins & Peptide

L3MBTL1, His-tag

SKU : BHP18200477

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Mfr.No.	55002
Description	Human lethal(3) malignant brain tumor-like protein 1 (L3MBTL1), GenBank Accession No. NM_015478, a.a. 191-530 with N-terminal His-tag, MW = 39.6 kDa, expressed in an E. coli cell expression system. host species: E. coli Host species: E. coli
Background	Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyl-lysine residues on target proteins, therey acting as a reader of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E atLys26 (H1bK26me1 and H1bK26me2) and histone H4 at Lys-20 (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at Lys-382, leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at Lys-860. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.
Immunogen Region	191-530
Tag	N-terminal His-tag
Formulation	40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Species	Human
Application	Useful for the study of Polycomb group (PcG) proteins, protein binding assays, screening inhibitors, and selectivity profiling.
Notes	Avoid freeze/thaw cycles.
GenBank	NM_015478
Mw(kda)	39.6 kDa

Synonyms	lethal(3) malignant brain tumor-like protein 1, L3MBTL1
Uniprot	Q9Y468

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Koga, H., et al., Oncogene. 1999 Jul 1;18(26):3799-809. 2. Trojer, P., et al., Cell. 2007 Jun 1;129(5):915-28. 3. Min, J., et al. Nat. Structl. & Mol. Biol. 2007;14:1229 - 1230.

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200477	55002	100 ug	$506		Add to Cart

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