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Home / Proteins & Peptide

Kallikrein 1, Human

SKU : BHP18500481

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iXCells Biotechnologies

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Mfr.No.	IX03363, IX03363-10
Description	Kallikrein 1 (KLK1), also known as tissue kallikrein, is a member of the human tissue kallikrein family. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis, and some have the potential to be used as cancer and other disease biomarkers. Human KLK1 precursor contains a signal peptide (residues 1 to 18), a short pro peptide (residues 19 to 24) and a mature chain (residues 25 to 262).Recombinant Human Kallikrein 1 produced in CHO cells is a polypeptide chain containing 292 amino acids. A fully biologically active molecule, rhKLK1 has a molecular mass of 46 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Formulation	Liquid after a 0.2 um filtered solution in 25 mM Tris-HCl, 75 mM NaCl,pH8.0.
Molecular Weight	46 kDa, observed by reducing SDS-PAGE.
Source	CHO
Accession Number	P06870
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	The Specific Activity is 1500 pmol/min/ug, Measured by hKLK1 s ability to cleave the fluorogenic peptide substrate Pro-Phe-Arg-AMC (Bachem, I-1295)Activation Buffer:50 mM Tris, 10 mM CaCl2, 150 mM NaCl, pH 7.5Assay Buffer: 50m M CHES, 250m M NaCl, pH 10.0Activate hKLK1: Dilute hKLK1 to 200 ug/ml in Activation Buffer;Dilute Thermolysin to 2ug/mL in Activation Buffer;Combine equal volumes of 200 ug/ml hKLK1 and 2 ug/ml Thermolysin;Incubate at 37 °C for 1 hour.

Synonyms	KLK1
Sequence	VTEHVLANND VSCDHPSNTV PSGSNQDLGA GAGEDARSDDSSSRIVGGWE CEQHSQPWQA ALYHFSTFQC GGILVHRQWVLTAAHCISDN YQLWLGRHNL FDDENTAQFV HVSESFPHPGFNMSLLENHT RQADEDYSHD LMLLRLTEPA DTITDAVKVVELPTEEPEVG STCLASGWGS IEPENFSFPD DLQCVDLKILPNDECKKAHV QKVTDFMLCV GHLEGGKDTC VGDSGGPLMCDGVLQGVTSW GYVPCGTPNK PSVAVRVLSY VKWIEDTIAENSHHHHHHHH HH

Purity	95% as analyzed by SDS-PAGE.
Storage	Recombinant Human Kallikrein 1 remains stable up to 6 months at lower than -70°C from date of receipt under sterile conditions. Up to 3 months at lower than -70°C under sterile conditions after opening. Avoid repeated freeze-thaw cycles.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500481-1	IX03363-10	10ug	$182		Add to Cart

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