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Home / Proteins & Peptide

IL-6, RhesusMacaque

SKU : BHP18500054

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iXCells Biotechnologies

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Mfr.No.	IX02759, IX02759-1, IX02759-10
Description	IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6Rª and gp130.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at -20 °C. Further dilutions should be made in appropriate buffered solutions.
Formulation	Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.
Molecular Weight	Approximately 21.1 kDa, a single non-glycosylated polypeptide chain containing 186 amino acids.
Physical Appearance	Sterile Filtered White lyophilized (freeze-dried) powder.
Source	E. coli
Host	RhesusMacaque
Usage	This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Endotoxin Level	Less than 1 EU/ug of rRhIL-6 as determined by LAL method.
Bioactivity	Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay usingIL-6-dependent murine 7TD1 cells is less than 0.1 ng/ml, corresponding to a specific activity of 1.0 x 107 IU/mg.

Synonyms	Interleukin-6 (IL-6), Rhesus Macaque;
Sequence	MAPVLPGEDS KNVAAPHSQP LTSSERIDKH IRYILDGISALRKETCNRSN?MCESSKEALA ENNLNLPKMA EKDGCFQSGF NEDTCLVKIITGLLEFEVYL?EYLQNRFESS EEQARAVQMS TKVLIQFLQK KAKNLDAITTPEPTTNASLL?TKLQAQNQWL QDMTTHLILR SFKEFLQSNL RALRQM

Purity	97 % by SDS-PAGE and HPLC analyses.
Storage	This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500054-1	IX02759-1	1mg	$2870		Add to Cart
BHP18500054-2	IX02759-10	10ug	$170		Add to Cart

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