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Home / Proteins & Peptide

IL-31, Human

SKU : BHP18500036

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iXCells Biotechnologies

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Mfr.No.	IX02717, IX02717-1, IX02717-10
Description	Human IL-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <= -20 °C. Further dilutions should be made in appropriate buffered solutions.
Formulation	Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH7.4.
Molecular Weight	Approximately 15.8 kDa, a single non-glycosylated polypeptide chain containing 141 amino acids.
Physical Appearance	Sterile Filtered White lyophilized (freeze-dried) powder.
Source	E. coli
Host	Human
Usage	This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Endotoxin Level	Less than 1 EU/ug of rHuIL-31 as determined by LAL method.
Bioactivity	Fully biologically active when compared to standard. The specific activity is determined by inducing STAT3 activation using human U-87 MG cells. 5 ng/mL of rHuIL-31 can effectively induce STAT3 activation.

Sequence	SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVLVSQNYTLPCL SPDAQPPNNI?HSPAIRAYLK TIRQLDNKSV IDEIIEHLDKLIFQDAPETN ISVPTDTHEC KRFILTISQQ?FSECMDLALK SLTSGAQQATT

Purity	97 % by SDS-PAGE and HPLC analyses.
Storage	This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500036-1	IX02717-1	1mg	$4492		Add to Cart
BHP18500036-2	IX02717-10	10ug	$199		Add to Cart

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