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Home / Proteins & Peptide

IL-2 R alpha, His, Human

SKU : BHP18500436

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iXCells Biotechnologies

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Mfr.No.	IX03297, IX03297-1, IX03297-10, IX03297-50
Description	Interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to the cytokine IL-2. The IL-2R is made up of 3 subunits - alpha (alpha), beta (beta) and gamma (gamma). The alpha and beta chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the gamma-chain, along with the beta subunit. The beta and gamma chains of the IL-2R are members of the type I cytokine receptor family. IL-2R has a high binding affinity to IL-2 and is expressed by antigen-activated T lymphocytes (T cells). IL-2 Ralpha is also known as CD25, p55, and Tac (activated T cell) antigen.Recombinant Human Interleukin-2 Receptor alpha (IL-2 R alpha), His produced in HEK 293 cells is a polypeptide chain containing 205 amino acids. A fully biologically active molecule, rhIL-2 R alpha has a molecular mass of 42 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	42 kDa, observed by reducing SDS-PAGE.
Source	HEK 293
Host	Human
Accession Number	P01589
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	Determined by its ability to increase the proliferation effect of IL-2 in murine CTLL-2 cells. In the presence of 1 ng/ml of recombinant IL-2, ED50 for this effect is 1.5 ug/ml.

Synonyms	soluble IL-2 receptor, TAC-antigen, CD25 antigen
Sequence	HHHHHHHHEL CDDDPPEIPH ATFKAMAYKE GTMLNCECKRGFRRIKSGSL YMLCTGNSSH SSWDNQCQCT SSATRNTTKQVTPQPEEQKE RKTTEMQSPM QPVDQASLPG HCREPPPWENEATERIYHFV VGQMVYYQCV QGYRALHRGP AESVCKMTHGKTRWTQPQLI CTGEMETSQF PGEEKPQASP EGRPESETSC

Purity	95% as analyzed by SDS-PAGE and HPLC.
Storage	Lyophilized recombinant Human Interleukin-2 Receptor alpha remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human Interleukin-2 Receptor alpha should be stable up to 1 week at 4°C or up to 3 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500436-1	IX03297-1	1mg	$1561		Add to Cart
BHP18500436-2	IX03297-10	10ug	$74		Add to Cart
BHP18500436-3	IX03297-50	50ug	$188		Add to Cart

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