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Home / Proteins & Peptide

IL-1beta, Mouse(CHO-expressed)

SKU : BHP18500193

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iXCells Biotechnologies

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Mfr.No.	IX02988, IX02988-1, IX02988-10, IX02988-50
Description	Interleukin-1 (IL-1) is a family of cytokines that play a central role in the regulation of immune and inflammatory responses to infections or sterile insults. IL-1alpha and IL-1beta are the first two members discovered in this family, which are the products of distinct genes recognizing the same cell surface receptors. IL-1alpha and IL-1beta are structurally related polypeptides that show approximately 25% homology at the amino acid level. Both proteins are produced by a wide variety of cells in response to stimuli such as those produced by inflammatory agents, infections, or microbial endotoxins. The proteins are synthesized as 31 kDa precursors that are subsequently cleaved into proteins with molecular weights of approximately 17.5 kDa. The specific protease responsible for the processing of IL-1beta is interleukin 1beta-converting enzyme (ICE)/caspase-1. Mature human and mouse IL-1beta share approximately 75% amino acid sequence identity where human IL-1beta has been found to be active on murine cell lines. iXCells Interleukin (IL)-1beta, murine, produced in CHO cells, is a non-glycosylated polypeptide chain containing 152 amino acids and having a molecular mass of 17,400 Da.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	17.4 kDa, observed by non-reducing SDS-PAGE.
Source	CHO
Host	Mouse
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	ED50 10 pg/ml, measured in a cell proliferation assay using D10S cells, corresponding to a specific activity of 1x108 units/mg.

Synonyms	Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)
Sequence	VPIRQLHYRL RDEQQKSLVL SDPYELKALH LNGQNINQQVIFSMSFVQGE PSNDKIPVAL GLKGKNLYLS CVMKDGTPTLQLESVDPKQY PKKKMEKRFV FNKIEVKSKV EFESAEFPNWYISTSQAEHK PVFLGNNSGQ DIIDFTMESV SS

Purity	95% as analyzed by SDS-PAGE and HPLC.
Storage	Lyophilized recombinant Murine Interleukin 1 beta (IL-1 beta) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rmIL-1beta should be stable up to 1 week at 4°C or up to 2 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500193-1	IX02988-1	1mg	$2097		Add to Cart
BHP18500193-2	IX02988-10	10ug	$95		Add to Cart
BHP18500193-3	IX02988-50	50ug	$312		Add to Cart

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