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Home / Proteins & Peptide

IGF-BP-4, His, Human

SKU : BHP18500337

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iXCells Biotechnologies

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Mfr.No.	IX03176, IX03176-1, IX03176-10, IX03176-50
Description	Insulin-like growth factor-binding protein 4 (IGF-BP-4), also known as IBP-4, is a secreted glycoprotein belonging to the IGFBP family. IGF-BP-4 is produced by osteoblasts, epidermis, ovarian follicles and other tissues. It binds both insulin-like growth factor (IGF) I and II, and it circulates in the plasma in both glycosylated and non-glycosylated forms. IGF-BP-4 prolongs the half-life of the IGFs and has been shown to inhibit or stimulate the growth-promoting effects of the IGFs. Pregnancy Associated Plasma Protein A (PAPP-A) proteolytically cleaves IGF-BP-4 and reduces its affinity to bind IGFs, and thus serves as an important regulator of IGF-BP-4 function.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	30-35 kDa, observed by reducing SDS-PAGE.
Source	HEK 293
Host	Human
Accession Number	P22692
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	ED50 50 ng/ml, measured in a bioassay using FDC-P1 cells in the presence of 15ng/ml human IGF-II.

Synonyms	Insulin-like Growth Factor-Binding Protein 4, IBP-4, HT29-IGF-BP, colon cancer cell growth inhibitor
Sequence	DEAIHCPPCS EEKLARCRPP VGCEELVREP GCGCCATCALGLGMPCGVYT PRCGSGLRCY PPRGVEKPLH TLMHGQGVCMELAEIEAIQE SLQPSDKDEG DHPNNSFSPC SAHDRRCLQKHFAKIRDRST SGGKMKVNGA PREDARPVPQ GSCQSELHRALERLAASQSR THEDLYIIPI PNCDRNGNFH PKQCHPALDGQRGKCWCVDR KTGVKLPGGL EPKGELDCHQ LADSFREHHHHHH

Purity	95% as analyzed by SDS-PAGE.
Storage	Lyophilized recombinant human IGF-BP-4 remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, human IGF-BP-4, His should be stable up to 1 week at 4°C or up to 2 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500337-1	IX03176-1	1mg	$2371		Add to Cart
BHP18500337-2	IX03176-10	10ug	$62		Add to Cart
BHP18500337-3	IX03176-50	50ug	$282		Add to Cart

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