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Home / Proteins & Peptide

I-309/CCL1, Human

SKU : BHP18500414

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Mfr.No.	IX03273, IX03273-25, IX03273-5
Description	Chemokine (C-C motif) ligand 1 (CCL1), also known as I-309, is a small glycoprotein secreted by activated T cells that belongs to the family ofchemokines. Human CCL1 has been assumed to be a homologue of mouse TCA3. While the two proteins share only approximately 42% amino acid sequence identity, both chemokines contain an extra pair of cysteine residues not found in most other chemokines. CCL1 attracts monocytes, NK cells, immature B cells and dendritic cells by interacting with the cell surface chemokine receptor CCR8. This chemokine resides in a large cluster of CC chemokines on human chromosome 17.Recombinant Human I-309/CCL1 produced in E.coli is a single non-glycosylated polypeptide chain containing 74 amino acids. A fully biologically active molecule, rhI-309/CCL1has a molecular mass of 8.5 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	8.5 kDa, observed by reducing SDS-PAGE.
Source	E. coli
Host	Human
Accession Number	P14210
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	The EC50 value of human I-309/CCL on Ca2+ mobilization assay in CHO-K1/Galpha15/hCCR8 cells (human Galpha15 and human CCR8 stably expressed in CHO-K1 cells) is less than 1 ug/ml.

Synonyms	CCL1, TCA-3
Sequence	SKSMQVPFSR CCFSFAEQEI PLRAILCYRN TSSICSNEGLIFKLKRGKEA CALDTVGWVQ RHRKMLRHCP SKRK

Purity	95% as analyzed by SDS-PAGE.
Storage	Lyophilized recombinant human I-309/CCL1 remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, recombinant human I-309/CCL1 should be stable up to 1 week at 4°C or up to 2 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500414-1	IX03273-25	25ug	$237		Add to Cart
BHP18500414-2	IX03273-5	5ug	$70		Add to Cart

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