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Home / Proteins & Peptide

Human VEGF-C protein, His Tag

SKU : BHP13700057

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Abbkine Scientific Co., Ltd.

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Mfr.No.	PRP100139
Description	Human VEGF-C protein, His Tag, expressed in HEK293 Cells
Alternative Names	Flt4-L; LMPH1D; VEGF-C; VRP; Vascular endothelial growth factor C; VEGFC
Background	Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF family. Upon biosynthesis, VEGF-C protein is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF-C protein is a dimeric glycoprotein, as a ligand for two receptors, VEGFR-3 (Flt4), and VEGFR-2. VEGF-C may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis. VEGF-C protein is over-expressed in various human cancers including breast cancer and prostate cancer. VEGF-C/VEGFR-3 axis, through different signaling pathways, plays a critical role in cancer progression by regulating different cellular functions, such as invasion, proliferation, and resistance to chemotherapy. Thus, targeting the VEGF-C/VEGFR-3 axis may be therapeutically significant for certain types of tumors.
Immunogen Region	PRP100139
Tag	VEGF-C
Formulation	Lyophilized from sterile PBS, pH 7.4
Molecular Weight	15.5 kDa
Usage	Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human VEGF-C protein, His Tag in sterile ddH2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.
Accession Number	NP_005420.1
Precautions	The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Bioactivity	1. Measured by its binding ability in a functional ELISA.Scatchard analysis showed the affinity constant (Kd) of recombinant human VEGF-C bound to recombinant human VEGFR3 was 1.4 nM.2. Measured in a cell proliferation assay using human umbilical vein endothelial cells (HUVEC).The ED50 for this effect is 0.1-0.5ug/mL.
Protein Length	The recombinant mature form of human VEGFC consists of 136 amino acids and has a predicted molecular mass of 15.5 kDa. In SDS-PAGE under reducing conditions, it migrates with an apparent molecular mass of 22-24 kDa due to glycosylation.
Others	The Endotoxin level is less than 1.0 EU per ug of the protein as determined by the LAL method Preparation Method: HEK293 Cells

Sequence	Amino acid sequence derived from mature form of human VEGFC (NP_005420.1) corresponding to amino acid (Thr 103-Arg 227) was expressed with a C-terminal polyhistidine tag.

Purity	> 97 % as determined by SDS-PAGE
Storage	Lyophilized Human VEGF-C protein, His Tagshould be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.47% HSA or BSA). Please prevent freeze-thaw cycles.

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SKU	Supplier No.	Size	Your price	Quantity
BHP13700057	PRP100139	5 ug	$129		Add to Cart
BHP13700057	PRP100139	100 ug	$779		Add to Cart
BHP13700057	PRP100139	1 mg	$5999		Add to Cart

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