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Home / Proteins & Peptide

Human TNFSF11 / Tumor necrosis factor ligand superfamily member 11 Recombinant Protein

SKU : BHP13800315

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	R0855h
Alternative Names	Osteoclast differentiation factor,ODF,Osteoprotegerin ligand,OPGL,Receptor activator of nuclear factor kappa-B ligand,RANKL,TNF-related activation-induced cytokine,TRANCE,CD254,OPGL,RANKL,TRANCE
Source	E.coli
Species	Homo Sapiens (Human)
Accession Number	NP_003692.1/ncbi
Endotoxin Level	<0.10 EU per 1 μg of the protein by the LAL method
Concentration	Reconstitution Dependent
Form	Liquid
Protein Name	Tumor necrosis factor ligand superfamily member 11
Entry Function	Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation.
Mw(kda)	12.98

Subunit	Homotrimer (By similarity). Interacts with TNFRSF11B (PubMed:22664871). Interacts with TNFRSF11A. Interacts with FBN1 (via N-terminal domain) in a Ca(+2)-dependent manner.
Gene Name	TNFSF11
Sequence	77-194aa

Purity	Greater than 95% by SDS-PAGE
Storage	Store at -20°C. (Avoid repeated freezing and thawing.)
Storage Buffer	50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)

Applications	Par, ELISA, AP, WB

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SKU	Supplier No.	Size	Your price	Quantity
BHP13800315	R0855h	50µg	$637.78		Add to Cart
BHP13800315	R0855h	100µg	$904.44		Add to Cart
BHP13800315	R0855h	200µg	$1348.89		Add to Cart
BHP13800315	R0855h	0.5mg	$1971.11		Add to Cart
BHP13800315	R0855h	1mg	$2682.22		Add to Cart
BHP13800315	R0855h	5mg	$4637.78		Add to Cart
BHP13800315	R0855h	10mg	$6148.89		Add to Cart

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