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Home / Proteins & Peptide

Human Synthetic Amyloid Beta 1-42 Oligomers

SKU : BHP11901218

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StressMarq Biosciences Inc.

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Mfr.No.	SPR-488, SPR-488B, SPR-488C, SPR-488E
Description	Human Synthetic Amyloid Beta 1-42 Oligomers
Alternative Names	Abeta Oligomers, Abeta peptide, Amyloid beta peptide oligomers, Beta amyloid peptide oligomers, amyloid beta precursor protein peptide oligomers, APP
Cellular Localization	Intracellular Vesicles, Cell Membrane
Certificate Of Analysis	Certified >95% pure using mass spec and HPLC.
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Scientific Background	Our Amyloid Beta 1-42 (Abeta42) Oligomers are generated from Amyloid Beta Peptide 1-42 pre-treated with 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) as previously published (1,2). Our Abeta42 oligomers present as globular oligomers when observed under TEM and AFM, and have a unique dimer/trimer and oligomer signal on a Western Blot with an anti-amyloid beta antibody. Our Abeta42 oligomers were also demonstrated to be toxic to primary rat cortical neurons in a dose-dependent manner. In the brain, amyloid beta peptide (Abeta) is generated by protease cleavage of amyloid precursor protein (APP), which aggregates into oligomers, protofibrils, fibrils and ultimately plaques in neurodegenerative diseases. The accumulation of Abeta plaques in the brain is considered a hallmark of Alzheimer s disease (AD), and most of the drugs tested for AD in the past 20 years have targeted amyloid beta accumulation (3). Soluble Abeta oligomers isolated from the brains of AD patients or those generated in vitro potently impaired synapse structure and function (4). Abeta oligomers generated in vitro were toxic to PC12 cells (5) and SH-SY5Y cells (6). Abeta was demonstrated to interact with tauopathies to affect neurodegeneration in AD patients (7) and accumulations of Abeta were shown to be associated with lower survival rates in Parkinson s disease patients with dementia (8).
Species	Human
Specificity	4.5 kDa
Host	Human
Concentration	Lot/batch specific. See included datasheet.
Purification	N/A
Expression System	N/A
Amino Acid Sequence	DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Cite This Product	Human Synthetic Amyloid Beta Oligomers (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPR-488)
Mol Weight	4.5 kDa
Mw(kda)	4.5 kDa
Nature	Synthetic (TFA preparation)
Protein Length	42 amino acids

Gross Weight (kg)	1.4
Launch Date	2022/03/03
Net Weight (g)	0.01
Swissprot	P05067
Target Details	Amyloid Beta Oligomers
Gene Id	351, 351
Research Area	Amyloid, Neurodegeneration, Alzheimer's Disease, Neuroscience
Target	Amyloid Beta, Amyloid Beta

Adr Code	Non-hazardous
Country Of Origin	Canada
Stock Product	Y
Tarriff Code	3822.19.0030
Un Code For Transport	Non-hazardous
Unspsc Code	12352202
Shipping Temperature	Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
Purity	>95%, >95%
Storage Buffer	Phosphate buffer (PB) pH 7.4 and 10 mM NaCl
Storage Temperature	-80°C

Applications	In vivo assay, In vitro assay, WB

Reference	1. Stine et al. 2003. JBC. 278(13):11612-22. doi: 10.1074/jbc.M210207200 2. Ahmed et al. 2010. Nature Structural & Molecular Biology. 17(5):561-7. doi: 10.1038/nsmb.1799 3. Panza et al. 2019. Nat Rev Neurol. 15:73-88 https://doi.org/10.1038/s41582-018-0116-6 4. Shankar et al. 2008. Nat Med. 14(8):837-842. doi: 10.1038/nm1782 5. Chromy et al. 2003. Biochemistry. 42:12749-12760. doi: 10.1021/bi030029q 6. Kayed et al. 2003. Science. 300(5618): 486-489. doi: 10.1126/science.1079469 7. Want et al. 2016. JAMA Neurol. 73(9):1070-7. doi: 10.1001/jamaneurol.2016.2078 8. Kotzbauer et al. 2012. Arch Neurol. 69(10): 1326-1331. doi: 10.1001/archneurol.2012.1609

Product Manual	Datasheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP11901218-1	SPR-488B	100 ug	$617		Add to Cart
BHP11901218-2	SPR-488C	100 ug x2	$988		Add to Cart
BHP11901218-3	SPR-488E	100 ug x5	$1998		Add to Cart

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