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Home / Proteins & Peptide

Human Sclerostin protein, His Tag

SKU : BHP13700059

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Abbkine Scientific Co., Ltd.

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Mfr.No.	PRP100151
Description	Human Sclerostin protein, His Tag, expressed in HEK293 Cells
Alternative Names	CDD; SOST1; VBCH; Sclerostin; SOST
Background	Sclerostin, the protein product of the SOST gene, is a potent inhibitor of bone formation. Sclerostin protein is widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteeoblasts differentiated for 21 days, and was originally identified as an important regulator of bone remodeling, homeostasis, and links bone resorption and bone apposition. Recent studies have revealed that Sclerostin protein inhibits the bone growth probably by binding to the extracellular domain of the Wnt coreceptors LRP5 and LRP6 and disrupting Wnt-induced Frizzled-LRP complex formation.
Immunogen Region	PRP100151
Tag	SOST
Formulation	Lyophilized from sterile PBS, pH 7.2
Molecular Weight	22.5 kDa
Usage	Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human Sclerostin protein, His Tag in sterile ddH2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.
Accession Number	NP_079513.1
Precautions	The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Protein Length	The recombinant human SOST is a monomeric protein consisting of 197 amino acids and predicts a molecular mass of 22.5 kDa. As a result of glycosylation, the apparent molecular mass of rhSOST is approximately 28 kDa in SDS-PAGE under reducing conditions..
Others	The Endotoxin level is less than 1.0 EU per ug of the protein as determined by the LAL method Preparation Method: HEK293 Cells

Sequence	Amino acid sequence derived from mature form of human SOST (NP_079513.1) (Gln 24-Tyr 213) was fused with a polyhistidine tag at the N-terminus.

Purity	> 90 % as determined by SDS-PAGE
Storage	Lyophilized Human Sclerostin protein, His Tagshould be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.49% HSA or BSA). Please prevent freeze-thaw cycles.

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SKU	Supplier No.	Size	Your price	Quantity
BHP13700059	PRP100151	50 ug	$1009		Add to Cart

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