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Home / Proteins & Peptide

Human Recombinant Transthyretin Y78F Variant Protein Monomers BHP11901157

SKU : BHP11901157

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StressMarq Biosciences Inc.

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Mfr.No.	SPR-452, SPR-452B, SPR-452C, SPR-452E
Description	Human Recombinant Transthyretin Y78F Variant Protein Monomers
Alternative Names	Amyloid polyneuropathy Protein Monomer, Amyloidosis I Protein Monomer, ATTR Protein Monomer, Carpal tunnel syndrome 1 Protein Monomer, CTS Protein Monomer, CTS1 Protein Monomer,= HEL111 Protein Monomer, HsT2651 Protein Monomer, PALB Protein Monomer, Prealbumin Protein Monomer, Prealbumin amyloidosis type I Protein Monomer, Prealbumin Thyroxine-binding Protein Monomer, TBPA Protein Monomer, Thyroxine binding prealbumin Protein Monomer, Transthyretin Protein Monomer, TTHY_HUMAN Protein Monomer,TTR Protein Monomer, TTR protein
Cellular Localization	Extracellular exosome, Cytoplasm, Extracellular Region, Lysosome
Certificate Of Analysis	Certified >95% pure using SDS-PAGE analysis.
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
Scientific Background	Transthyretin is a transport protein in the serum and cerebospinal fluid that carried the thyroid hormone Thyroxine and retinol-binding protein bound to retinol. TTR misfolding and aggregation is known to be associated with the amyloiddiseases SSA, FAP and FAC (1-5). TTR is also thought to have beneficial side effects, such as binding to beta-amyloid protein, preventing beta-amyloid from accumulating into the plaques associated with Alzheimer's Disease (6). The mutant variant Y78F indicates a destabilization of the contacts between the alpha-helix and AB loop and the body of the molecule, potentially leading to applications in immne therapy for FAP (7).
Species	Human
Accession Number	NP_000362.1
Concentration	Lot/batch specific. See included datasheet.
Purification	Ion-exchange Purified
Expression System	E. coli
Biological Activity Abreviation	Under Investigation
Cite This Product	Human Recombinant TTR Protein (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPR-452E)
Mol Weight	15.887 kDa
Nature	Recombinant
Protein Length	Full length

Gross Weight (kg)	1.4
Launch Date	03-18-2019
Net Weight (g)	0.5
Swissprot	P02766
Gene Id	7276
Research Area	Tangles & Tau, Neurodegeneration, Alzheimer's Disease, Parkinson's Disease, Synuclein, Neuroscience
Target	Transthyretin

Country Of Origin	Canada
Stock Product	Y
Tarriff Code	3822.00.1090
Shipping Temperature	Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
Purity	>95%
Storage Buffer	PBS pH 7.4
Storage Temperature	-80°C

Applications	In vivo assay, In vitro assay, WB, SDS-PAGE

Reference	1. Nemoto, T. et al. (1997) J.Biol Chem. 272: 26179-26187. 2. Minami, Y, et al. (1991), J.Biol Chem. 266: 10099-10103. 3. Arlander SJH, et al. (2003) J Biol Chem. 278: 52572-52577. 4. Pearl H, et al. (2001) Adv Protein Chem. 59: 157-186. 5. Neckers L, et al. (2002) Trends Mol Med. 8: S55-S61. 6. Pratt W, Toft D. (2003) Exp Biol Med. 228: 111-133. 7. Pratt W, Toft D. (1997) Endocr Rev. 18: 306- 360. 8. Pratt WB. (1998) Proc Soc Exptl Biol Med. 217: 420- 434. 9. Whitesell L, et al. (1994) Proc Natl Acad Sci USA. 91: 8324- 8328. 10. Nemoto, T. (1997) Biochem and Mol. Bio Intl. 42 (5): 881-889.

Product Manual	Datasheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP11901157-1	SPR-452B	100 ug	$427		Add to Cart
BHP11901157-2	SPR-452C	2X100 ug	$682		Add to Cart
BHP11901157-3	SPR-452E	5X100 ug	$1386		Add to Cart

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