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Home / Proteins & Peptide

Human Recombinant Tau-441 (2N4R) Wild-Type Pre-formed Fibrils (Baculovirus/Sf9)

SKU : BHP11901226

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StressMarq Biosciences Inc.

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Mfr.No.	SPR-498, SPR-498B, SPR-498C, SPR-498E
Alternative Names	MAPT, intracellular neurofibrillary tangles, NFTs, paired helical filaments, PHFs, 2N4R
Certificate Of Analysis	Protein certified >95% pure on SDS-PAGE & Nanodrop analysis. Low endotoxin, <5EU/mL.
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
Scientific Background	Brain-specific tau isoforms vary in the number of N-terminal inserts and C- terminal repeat domains due to alternative splicing of exons; the 2N4R isoform of tau is expressed in adult brain yet is absent from the fetal brain (1). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as Alzheimer s Disease (AD) are characterized by neurofibrillary tangles containing hyper-phosphorylated tau fibrils (2). Hyper-phosphorylated tau can be generated via expression in the Sf9/Baculovirus system, with up to 20 sites confirmed by mass spectrometry and Western Blots with phospho-specific antibodies(3). Sf9/Baculovirus-expressed Tau 2N4R Pre-Formed Fibrils are generated without heparin.
Species	Human
Specificity	45.84 kDa
Concentration	Lot/batch specific. See included datasheet.
Purification	Ion-exchange Purified
Expression System	Baculovirus (Sf9)
Amino Acid Sequence	MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Cite This Product	Human Recombinant Tau-441 (2N4R) Wild-Type Pre-formed Fibrils (Baculovirus/Sf9) (StressMarq Biosciences Inc. \| Victoria BC CANADA \| Catalog # SPR-498B)
Nature	Recombinant
Protein Length	Full Length (1-441 aa)

Gross Weight (kg)	1.4
Launch Date	2023/10/13
Net Weight (g)	0.01
Swissprot	P10636-8
Target Details	Tau-441 (2N4R) Wild-Type
Research Area	Tangles & Tau, Neurodegeneration, Alzheimer's Disease, Neuroscience

Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090
Un Code For Transport	Non-hazardous
Unspsc Code	12352202
Shipping Temperature	Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
Purity	>95%
Storage Buffer	1X PB pH7.4
Storage Temperature	-80°C

Applications	SDS PAGE, In vitro assay, WB

Reference	1. Goedert et al. 1989. Multiple Isoforms of Human Microtubule-associated Protein Tau: Sequences and Localization in Neurofibrilary Tangles of Alzheimer s Disease. Neuron. doi: 10.1016/0896-6273(89)90210-9. 2. Iqbal K., Liu F., and Gong C.X. 2016. Tau and neurodegenerative disease: The story so far. Nat. Rev. Neurol. DOI: 10.1038/nrneurol.2015.225 3. Tepper et al. 2014. Oligomer Formation of Tau Protein Hyperphophorylated in Cells. The Journal of Biological Chemistry, DOI 10.1074/jbc.M114.611368

Product Manual	Datasheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP11901226-1	SPR-498B	100 ug	$840		Add to Cart
BHP11901226-2	SPR-498C	2x100 ug	$1343		Add to Cart
BHP11901226-3	SPR-498E	5x100 ug	$2728		Add to Cart

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