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Home / Proteins & Peptide

Human Recombinant Superoxide dismutase Protein Pre-formed Fibrils BHP11901190

SKU : BHP11901190

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StressMarq Biosciences Inc.

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Mfr.No.	SPR-470, SPR-470B, SPR-470C, SPR-470E
Description	Human Recombinant Superoxide dismutase Protein Pre-formed Fibrils
Alternative Names	Superoxide dismutase1 Protein, ALS1 Protein , SOD1 Protein, IPOA Protein
Cellular Localization	Nucleus, Mitochondrion, Cytoplasm
Certificate Of Analysis	Certified >95% pure using SDS-PAGE analysis.
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
Scientific Background	Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body (3). It works by catalyzing the dismutation of the superoxide radical O2? to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (2,5). In general, SODs play a major role in antioxidant defense mechanisms (4). There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge (3). The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extra-cellular space (7). SOD3 can also be distinguished by its heparin-binding capacity (1). Studies have shown that in vitro, Cu-Zn SOD (SOD1) fibrils are transduced into cells and function as seeds to trigger the aggregation of endogenously expressed SOD1 (9).
Species	Human
Accession Number	NP_000445.1
Concentration	Lot/batch specific. See included datasheet.
Purification	Ion-exchange Purified
Expression System	E. coli
Biological Activity Abreviation	Under Investigation
Cite This Product	Human Recombinant SOD Protein (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPR-470E)
Mol Weight	15.936 kDa
Nature	Recombinant
Protein Length	Full length

Gross Weight (kg)	1.4
Launch Date	03-18-2019
Net Weight (g)	0.5
Swissprot	P00441
Gene Id	6647
Research Area	Cancer, Oxidative Stress, Cell Signaling, Chaperone Proteins, Protein Trafficking
Target	Superoxide Dismutase

Country Of Origin	Canada
Stock Product	Y
Tarriff Code	3822.00.1090
Shipping Temperature	Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
Purity	>95%
Storage Buffer	PB pH 7.4, 5 mM EDTA, 50 mM DTT
Storage Temperature	-80°C

Applications	In vivo assay, In vitro assay, WB, SDS-PAGE

Reference	1. Arlander SJH, et al. (2003) J Biol Chem 278: 52572-52577. 2. Pearl H, et al. (2001) Adv Protein Chem 59:157-186. 3. Neckers L, et al. (2002) Trends Mol Med 8:S55-S61. 4. Pratt W, Toft D. (2003) Exp Biol Med 228:111-133. 5. Pratt W, Toft D. (1997) Endocr Rev 18: 306- 360. 6. Pratt WB. (1998) Proc Soc Exptl Biol Med 217: 420- 434. 7. Whitesell L, et al. (1994) Proc Natl Acad Sci USA 91: 8324- 8328. 8. Perdew, G. H. (1988) JBC 263 (27): 13802-13805 9. Dalman, F. C. et al.(1989) JBC 264(33): 19815-19821 10. Uma, S. et al. (1997) JBC 272(17): 11648-11656.

Product Manual	Datasheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP11901190-1	SPR-470B	100 ug	$460		Add to Cart
BHP11901190-2	SPR-470C	2X100 ug	$736		Add to Cart
BHP11901190-3	SPR-470E	5X100 ug	$1496		Add to Cart

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