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Home / Proteins & Peptide

Human Recombinant Alpha Synuclein S87N Mutant Monomers

SKU : BHP11901227

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StressMarq Biosciences Inc.

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Mfr.No.	SPR-499, SPR-499B, SPR-499C, SPR-499E
Alternative Names	Alpha Synuclein S87N, Alpha synuclein protein, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, SYN protein, Parkinson's disease familial 1 Protein
Certificate Of Analysis	Protein certified >95% pure on SDS-PAGE & Nanodrop analysis
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
Scientific Background	Human alpha synuclein S87N mutant (HuS87N) has Ser87 mutated to the equivalent mouse residue Asn87, effectively making it a human-mouse chimeric protein. <br /><br />Despite sequence differences at only seven residues, or 5% of the total 140 amino acids, the aggregation rate of wild-type mouse alpha-syn (MsWT) is faster than wild-type human alpha-syn (HuWT) in vitro. In wild-type mouse models, MsWT fibrils are more efficient than HuWT fibrils at inducing pathology of endogenous mouse alpha-syn (1). A53T or S87N substitutions in human alpha-syn substantially accelerate fibrilization rates in vitro (2,3).<br />Chimeric HuS87N fibrils show enhanced pathogenicity to wild-type mouse neurons, greater than HuWT, HuA53T, and MsWT fibrils (4). HuS87N fibrils can be used as a more human-like alternative to MsWT fibrils to induce equivalent or greater endogenous alpha-syn seeding and pathology in wild-type mice.
Species	Human
Specificity	14.46 kDa
Accession Number	NP_000336.1
Concentration	Lot/batch specific. See included datasheet.
Purification	Ion-exchange Purified
Expression System	E. coli
Amino Acid Sequence	MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGNIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA
Biological Activity Abreviation	Active
Cite This Product	Human Recombinant Alpha Synuclein S87N Monomers (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPR-499)
Nature	Recombinant
Protein Length	140 AA

Gross Weight (kg)	1.4
Launch Date	2023/08/25
Net Weight (g)	0.01
Swissprot	P37840-1
Target Details	Alpha Synuclein S87N Mutant
Gene Id	6622
Research Area	Tangles & Tau, Multiple System Atrophy, Neurodegeneration, Alzheimer's Disease, Parkinson's Disease, Synuclein, Neuroscience

Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.19.0030
Un Code For Transport	Non-hazardous
Unspsc Code	12352202
Shipping Temperature	Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
Purity	>95%
Storage Buffer	1X PBS pH 7.4
Storage Temperature	-80°C

Applications	SDS PAGE, In vitro assay, WB

Reference	1. Masuda-Suzukake et al. 2013. Prion-like Spreading of Pathological alpha-synuclein in Brain. Brain. https://doi.org/10.1093/brain/awt037<br />2. Kang, K. et al. 2011. The A53T Mutation is Key in Defining the Differences in the Aggregation Kinetics of Human and Mouse alpha-synuclein. JACS. https://doi.org/10.1021/ja203979j<br />3. Ohgita, T. et al. 2023. Intramolecular Interaction Kinetically Regulates Fibril Formation by Human and Mouse Alpha-Synuclein. Sci Rep https://doi.org/10.1038/s41598-023-38070-4<br />4. Luk, K., C. et al. 2016. Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity. Cell Rep. https://doi.org/10.1016/j.celrep.2016.08.053

Product Manual	Datasheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP11901227-1	SPR-499B	100 ug	$382		Add to Cart
BHP11901227-2	SPR-499C	2x100 ug	$611		Add to Cart
BHP11901227-3	SPR-499E	5x100 ug	$1240		Add to Cart

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