Alpha Synuclein Protein

Mfr.No.	SPR-321, SPR-321B, SPR-321C, SPR-321XE, SPR-321E, SPR-321XG
Description	Active Human Recombinant Alpha Synuclein Protein Monomers (Type 1), Active Human Recombinant Alpha Synuclein Protein Monomers (Type 1)
Alternative Names	Alpha synuclein monomer, Alpha-synuclein monomer, Alpha synuclein protein monomer, Alpha synuclein monomer, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, Alpha synuclein monomers, SYN protein, Parkinson's disease familial 1 Protein
Biological Activity	100 uM alpha synuclein protein monomer (SPR-321) seeded with 10 uM alpha synuclein PFFs (SPR-322) in 25 uM Thioflavin T (PBS pH 7.4, 100 ul reaction volume) generated a fluorescence intensity of 13,000 Relative Fluorescence Units after incubation at 37°C with shaking at 600 rpm. Fluorescence was measured by excitation at 450 nm and emission at 485 nm on a Molecular Devices Gemini XPS microplate reader.
Cellular Localization	Cytoplasm, Membrane, Nucleus
Certificate Of Analysis	Certified >95% pure using SDS-PAGE analysis.
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
Regulatory	RUO
Scientific Background	Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).
Species	Human
Specificity	~14.46 kDa
Accession Number	NP_000336.1
Concentration	Lot/batch specific. See included datasheet.
Purification	Ion-exchange Purified
Expression System	E. coli
Amino Acid Sequence	MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Bioactivity	100 uM alpha synuclein protein monomer (SPR-321) seeded with 10 uM alpha synuclein PFFs (SPR-322) in 25 uM Thioflavin T (PBS pH 7.4, 100 ul reaction volume) generated a fluorescence intensity of 13,000 Relative Fluorescence Units after incubation at 37°C with shaking at 600 rpm. Fluorescence was measured by excitation at 450 nm and emission at 485 nm on a Molecular Devices Gemini XPS microplate reader.
Biological Activity Abreviation	Active
Biological Activity Comment	101 µM alpha synuclein protein monomer (SPR-321) seeded with 10 nM alpha synuclein PFF (SPR-322) in 25 µM Thioflavin T (PBS pH 7.4, 100 µl reaction volume) generated a fluorescence intensity of 13,000 Relative Fluorescence Units after incubation at 37°C w8@daC Go Anti-it (eet 䌰셥ǟ結塷翹our atT.ocဘ쀂r Bal䌰셥ǟepidermis, andecr of epi
Cite This Product	Human Recombinant Alpha Synuclein Protein (StressMarq Biosciences, Canada, Cat # SPR-321B)
Mol Weight	~14.46 kDa
Nature	Recombinant
Protein Length	Full Length

Gross Weight (kg)	1.4
Launch Date	2016/11/08
Net Weight (g)	0.1
Swissprot	P37840
Target Details	Alpha Synuclein
Gene Id	6622
Research Area	Tangles & Tau, Multiple System Atrophy, Alzheimer's Disease, Neurodegeneration, Parkinson's Disease, Synuclein, Neuroscience
Target	Alpha Synuclein

Adr Code	Non-hazardous
Country Of Origin	Canada
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Shipping	Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
Stock Product	Y
Tarriff Code	3822.19.0030
Un Code For Transport	Non-hazardous
Unspsc Code	12352202
Shipping Temperature	Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
Buffer	PBS pH 7.4
Description	Accession Number: NP_000336.1 Specificity: ~14.46 kDa Certificate of Analysis: Certified >95% pure using SDS-PAGE analysis. Country of Origin: Canada Gross Weight (kg): 1.4 Net Weight (g): 0.1 Stock Product: Y
Purity	>95%
Storage Buffer	PBS pH 7.4
Storage Temperature	-80°C

Immunogen Species	Homo Sapiens (Human)
Applications	In vivo assay, In vitro assay, WB, SDS-PAGE

Reference	1. Genetics Home Reference: SNCA. US National Library of Medicine. (2013). 2. Zhang L., et al. (2008) Brain Res. 1244: 40-52. 3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117. 4. Kokhan V.S., Afanasyeva M.A., Van'kin G. (2012) Behav. Brain. Res. 231(1): 226-230. 5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840. 6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757.

Product Manual	Datasheet
SDS

No Description Available.

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Combination SKU	Supplier No.	Size	Your price
BHP11900139-1	SPR-321B	100 ug	$382	Add to Cart
BHP11900139-2	SPR-321C	100 ug x2	$611	Add to Cart
BHP11900139-3	SPR-321XE	500 ug (5 mg/ml)	$1178	Add to Cart
BHP11900139-4	SPR-321E	100 ug x5	$1240	Add to Cart
BHP11900139-5	SPR-321XG	500 ug x2 (5 mg/ml)	$2121	Add to Cart

Human Recombinant Alpha Synuclein Protein Monomers (Type 1)

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