Alpha Synuclein Protein

Mfr.No.	SPR-484, SPR-484B, SPR-484C, SPR-484E
Description	Human Recombinant Alpha Synuclein Oligomers (Kinetically Stable)
Alternative Names	Alpha synuclein pre-formed fibrils, Alpha synuclein aggregates, Alpha synuclein protein aggregates, Alpha synuclein aggregates, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, SYN protein, Parkison disease familial 1 Protein
Cellular Localization	Presynaptic Termini, Cytoplasm, Cell Membrane, Nucleus
Certificate Of Analysis	Certified >95% pure using Native-PAGE analysis.
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
Scientific Background	Our kinetically stable oligomers of alpha-synuclein are generated without an inducer or inhibitor and remain stable for at least 2 weeks at 37oC. They present as globular structures under TEM, demonstrate toxicity in rat primary dopaminergic neurons and induce Parkinson s-associated alpha synuclein phosphoserine 129 pathology. These oligomers have been previously characterized as globular, cylindrical structures with a beta-sheet structure intermediate between monomers and fibrils, and were demonstrated to have a higher toxicity to neurons than alpha-synuclein fibrils (1,2). Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (3). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (4). Functionally, it has been shown to significantly interact with tubulin (5), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (6). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimer s disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (7, 8).
Species	Human
Specificity	650-1200 kDa
Host	Human
Accession Number	NP_000336.1
Concentration	Lot/batch specific. See included datasheet.
Purification	Ion-eXchange Purified, monomer removed with 100K MWCO filter, Ion-exchange Purified, monomer removed with 100K MWCO filter
Expression System	E. coli
Amino Acid Sequence	MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Cite This Product	Human Recombinant Alpha Synuclein Oligomers (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPR-484B)
Mol Weight	650-1200 kDa
Mw(kda)	650-1200 kDa
Nature	Recombinant
Other Relevant Information	Kinetically stable a-syn oligomers are generated from recombinant monomer without an inducer/inhibitor, remain soluble oligomers for at least two weeks at 37 degrees, and are toxic to dopaminergic neurons.
Protein Length	Full Length

Gross Weight (kg)	1.4
Launch Date	2021/10/25
Net Weight (g)	0.01
Swissprot	P37840
Target Details	Alpha Synuclein Oligomers (Kinetically Stable)
Gene Id	6622, 6622
Research Area	Tangles & Tau, Multiple System Atrophy, Neurodegeneration, Alzheimer's Disease, Parkinson's Disease, Synuclein, Neuroscience
Target	Alpha Synuclein, Alpha Synuclein

Adr Code	Non-hazardous
Country Of Origin	Canada
Stock Product	Y
Tarriff Code	3822.19.0030
Un Code For Transport	Non-hazardous
Unspsc Code	12352202
Shipping Temperature	Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
Purity	>95%, >95%
Storage Buffer	PB pH 7.4 (10 mM KH2PO4, 7.5 mM NaOH, pH 7.4)
Storage Temperature	-80°C

Applications	Native PAGE, In vivo assay, In vitro assay, WB

Reference	1. Chen, S.W., et. al. (2015). PNAS. E1994-E2003. 2. Lorenzen, N., et. al. (2014). JACS. 136: 3859-3868. 3. Genetics Home Reference: SNCA. US National Library of Medicine. (2013). 4. Zhang L., et al. (2008) Brain Res. 1244: 40-52. 5. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117. 6. Kokhan V.S., Afanasyeva M.A., Van'kin G. (2012) Behav. Brain. Res. 231(1): 226-230. 7. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840. 8. Mezey E., et al. (1998) Nat Med. 4(7): 755-757.

Product Manual	Datasheet

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Combination SKU	Supplier No.	Size	Your price
BHP11901215-1	SPR-484B	100 ug	$840	Add to Cart
BHP11901215-2	SPR-484C	100 ug x2	$1343	Add to Cart
BHP11901215-3	SPR-484E	100 ug x5	$2728	Add to Cart

Human Recombinant Alpha Synuclein Oligomers (Kinetically Stable)

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