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Home / Proteins & Peptide

Human Recombinant AHA1 Protein (Multi-Step Purified)

SKU : BHP11900091

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StressMarq Biosciences Inc.

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Mfr.No.	SPR-300, SPR-300A, SPR-300B, SPR-300C
Alternative Names	Aha1 Protein, SHSA1 Protein, HSPC322 Protein, p38 Protein
Cellular Localization	Cytoplasm
Certificate Of Analysis	This product has been certified >90% pure using SDS PAGE analysis. 2uM SPR-300 generated a 9-fold ATPase activation of 2uM HSP90 (His-tagged HSP90 beta) in 33mM Hepes pH7.2, 30mM NaCl, 5mM MgCl2, 1mM DTT, 1.5mM ATP in a 100ul reaction at 37 degrees C. (This is an enzyme-linked ATP regeneration assay tracking loss of NADH absorbance at 340nm.)
Description	Human Recombinant AHA1 Protein
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
Regulatory	RUO
Scientific Background	Aha1 is a member of the HSP90 cochaperone family, and is thought to stimulate HSP90 ATPase activity by competing with p23 and other co-chaperones for HSP90 binding (1, 2). It may affect a step in the endoplasmic reticulum to Golgi trafficking. Aha1 also interacts with HSPCA/HSP90 and with the cytoplasmic tail of the vesicular stomatistis virus glycoproteins (VSV G) (3). Aha1 is expressed in numerous tissues, including the brain, heart, skeletal muscle, and kidney, and at low levels, the liver and placenta. Aha1 might be a potential therapeutic strategy to increase sensitivity to HSP inhibitors (4).
Species	Human
Specificity	~38 kDa
Accession Number	NP_036243.1
Concentration	Lot/batch specific. See included datasheet.
Purification	Multi-Step Purified
Expression System	E. coli
Amino Acid Sequence	SHMAKWGEGDPRWIVEERADATNVNNWHWTERDASNWSTDKLKTLFLAVQVQNEEGKCEVTEVSKLDGEASINNRKGKLIFFYEWSVKLNWTGTSKSGVQYKGHVEIPNLSDENSVDEVEISVSLAKDEPDTNLVALMKEEGVKLLREAMGIYISTLKTEFTQGMILPTMNGESVDPVGQPALKTEERKAKPAPSKTQARPVGVKIPTCKITLKETFLTSPEELYRVFTTQELVQAFTHAPATLEADRGGKFHMVDGNVSGEFTDLVPEKHIVMKWRFKSWPEGHFATITLTFIDKNGETELCMEGRGIPAPEEERTRQGWQRYYFEGIKQTFGYGARLF
Cite This Product	Human Recombinant AHA1 Protein (StressMarq Biosciences, Canada, Cat # SPR-300A)
Mol Weight	~38 kDa
Nature	Recombinant

Gross Weight (kg)	1.4
Launch Date	2009/07/31
Net Weight (g)	0.05
Number Of Pubmed Citations	1
Swissprot	O95433
Target Details	AHA1
Gene Id	10598
Research Area	Cancer, Heat Shock, Cell Signaling, Chaperone Proteins, Protein Trafficking
Target	AHA1

Adr Code	Non-hazardous
Country Of Origin	Canada
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Published Application	ATPase activity assay
Pubmed Id	23703283
Shipping	Blue Ice or 4ºC
Stock Product	Y
Tarriff Code	3822.19.0030
Un Code For Transport	Non-hazardous
Unspsc Code	12352202
Shipping Temperature	Blue Ice or 4°C
Buffer	20mM HEPES buffer pH7.2, 80mM NaCl, 10% glycerol
Description	Accession Number: NM_036243.1 Specificity: ~38 kDa Certificate of Analysis: This product has been certified >90% pure using SDS PAGE analysis. 2uM SPR-300 generated a 9-fold ATPase activation of 2uM HSP90 (His-tagged HSP90 beta) in 33mM Hepes pH7.2, 30mM NaCl, 5mM MgCl2, 1mM DTT, 1.5mM ATP in a 100ul reaction at 37 degrees C. (This is an enzyme-linked ATP regeneration assay tracking loss of NADH absorbance at 340nm.) Country of Origin: Canada Gross Weight (kg): 1.4 Net Weight (g): 0.05 Stock Product: Y
Purity	>90%
Storage Buffer	20mM HEPES buffer pH7.2, 80mM NaCl, 10% glycerol
Storage Temperature	-20°C

Immunogen Species	Homo Sapiens (Human)
Applications	Functional assay, WB, SDS-PAGE

Reference	1. Hainzl O., Lapina M.C., Buchner J., Richter K. (2009) J Biol Chem. Epub. 2. Harst A., Lin H., Obermann W.M. (2005) Biochem J. 387 (pt.3): 789-796. 3. Lotz G.P., Brychzy A., Heinz S., Obermann W.M. (2008) J Cell Sci. 121(pt.5): 717-723. 4. Holmes J.L., Sharp S.Y., Hobbs S., Workman P. (2008) Cancer Res. 68(4): 1188-1197.

Product Manual	Datasheet
SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP11900091-1	SPR-300A	50 ug	$226		Add to Cart
BHP11900091-2	SPR-300B	100 ug	$358		Add to Cart
BHP11900091-3	SPR-300C	100 ug x2	$572		Add to Cart

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