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Home / Proteins & Peptide

Human PIK3CA / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Recombinant Protein

SKU : BHP13800257

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	R14307h
Alternative Names	Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha,PtdIns-3-kinase subunit p110-alpha,Phosphoinositide-3-kinase catalytic alpha polypeptide,Serine/threonine protein kinase PIK3CA,2.7.11.1
Source	E.coli
Species	Homo Sapiens (Human)
Accession Number	P42336
Endotoxin Level	<0.10 EU per 1 μg of the protein by the LAL method
Concentration	Reconstitution Dependent
Form	Liquid
Protein Name	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Entry Function	Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Also has serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Plays a role in the positive regulation of phagocytosis and pinocytosis.
Mw(kda)	23.21

Subunit	Heterodimer of a catalytic subunit PIK3CA and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3) (PubMed:26593112). Interacts with IRS1 in nuclear extracts (By similarity). Interacts with RUFY3 (By similarity). Interacts with RASD2 (By similarity). Interacts with APPL1. Interacts with HRAS and KRAS (By similarity). Interaction with HRAS/KRAS is required for PI3K pathway signaling and cell proliferation stimulated by EGF and FGF2 (By similarity). Interacts with FAM83B; activates the PI3K/AKT signaling cascade (PubMed:23676467).
Gene Name	PIK3CA
Sequence	520-730aa

Purity	Greater than 95% by SDS-PAGE
Storage	Store at -20°C. (Avoid repeated freezing and thawing.)
Storage Buffer	50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)

Applications	Par, ELISA, AP, WB

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SKU	Supplier No.	Size	Your price	Quantity
BHP13800257	R14307h	50µg	$637.78		Add to Cart
BHP13800257	R14307h	100µg	$904.44		Add to Cart
BHP13800257	R14307h	200µg	$1348.89		Add to Cart
BHP13800257	R14307h	0.5mg	$1971.11		Add to Cart
BHP13800257	R14307h	1mg	$2682.22		Add to Cart
BHP13800257	R14307h	5mg	$4637.78		Add to Cart
BHP13800257	R14307h	10mg	$6148.89		Add to Cart

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