Human IL10R Protein, hFc Tag

Mfr.No.	PME100879
Description	Recombinant human IL10R protein with C-terminal human Fc tag
Background	The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressIVe signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote surVIVal of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. ActIVation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. (proVIded by RefSeq, Jan 2009)
Tag	C-Human Fc tag
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Molecular Weight	The protein has a predicted molecular mass of 50.5 kDa after removal of the signal peptide. The apparent molecular mass of IL10R-hFc is approXimately 70-100 kDa due to glycosylation.
Host	HEK293
Notes	Research use only

Purity	The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
Storage	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Have you used this product?

SKU	Supplier No.	Size	Your price
BHP18100197	PME100879	100 ug	$568	Add to Cart
BHP18100197	PME100879	50 ug	$388	Add to Cart
BHP18100197	PME100879	10 ug	$103	Add to Cart