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Home / Proteins & Peptide

Human IL-15 protein, His Tag

SKU : BHP13700049

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Abbkine Scientific Co., Ltd.

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Mfr.No.	PRP100103
Description	Human IL-15 protein, His Tag, expressed in E. coli
Alternative Names	IL-15; Interleukin 15; Interleukin-15; IL15
Background	The protein encoded by IL-15 is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL-2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported.
Immunogen Region	PRP100103
Tag	IL-15
Formulation	Lyophilized from sterile PBS, pH 7.4.
Molecular Weight	14.9 kDa
Usage	Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human IL15 protein, His Tag in sterile ddH2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.
Accession Number	NP_000576.1
Precautions	The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Bioactivity	Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells.The ED50 for this effect is typically 10-40 ng/mL.
Protein Length	The recombinant human IL-15 consists of 130 amino acids and predicts a molecular mass of 14.9 KDa. It migrates as an approximately 15 KDa band in SDS-PAGE under reducing conditions.
Others	Preparation Method: E. coli

Sequence	Amino acid sequence derived from human IL-15 (NP_000576.1) (Asn18-Ser162) was expressed with a polyhistidine tag at the N-terminus.

Purity	> 95 % as determined by SDS-PAGE
Storage	Lyophilized Human IL-15 protein, His Tagshould be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.39% HSA or BSA). Please prevent freeze-thaw cycles.

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SKU	Supplier No.	Size	Your price	Quantity
BHP13700049	PRP100103	10 ug	$349		Add to Cart
BHP13700049	PRP100103	100 ug	$1559		Add to Cart
BHP13700049	PRP100103	1 mg	$5719		Add to Cart

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