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Home / Proteins & Peptide

Human CD74 / HLA class II histocompatibility antigen gamma chain Recombinant Protein

SKU : BHP13800157

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	R13627h
Alternative Names	HLA-DR antigens-associated invariant chain,Ia antigen-associated invariant chain,Ii,p33,CD74,DHLAG
Antigen	CD74
Source	E.coli
Species	Homo Sapiens (Human)
Accession Number	NP_004346.1/ncbi
Endotoxin Level	<0.10 EU per 1 μg of the protein by the LAL method
Concentration	Reconstitution Dependent
Form	Liquid
Protein Name	HLA class II histocompatibility antigen gamma chain
Entry Function	Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
Mw(kda)	13.64

Subunit	Homotrimer. In the endoplasmic reticulum (ER) it forms a heterononameric MHC II-Ii complex: 3 MHC class II molecules (heterodimers of an alpha and a beta subunit) bind to the CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system, the CD74 component undergoes sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide) attached to the MHC class II molecule (alpha-beta-CLIP complex). This processed complex interacts with HLA_DM and HLA_DO heterodimers in order to release CLIP and facilitate the binding of antigenic peptides to the MHC class II molecules.
Gene Name	CD74
Sequence	77-200aa

Purity	Greater than 95% by SDS-PAGE
Storage	Store at -20°C. (Avoid repeated freezing and thawing.)
Storage Buffer	50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)

Applications	Par, ELISA, AP, WB

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SKU	Supplier No.	Size	Your price	Quantity
BHP13800157	R13627h	50µg	$637.78		Add to Cart
BHP13800157	R13627h	100µg	$904.44		Add to Cart
BHP13800157	R13627h	200µg	$1348.89		Add to Cart
BHP13800157	R13627h	0.5mg	$1971.11		Add to Cart
BHP13800157	R13627h	1mg	$2682.22		Add to Cart
BHP13800157	R13627h	5mg	$4637.78		Add to Cart
BHP13800157	R13627h	10mg	$6148.89		Add to Cart

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