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Home / Proteins & Peptide

Human CD73/NT5E protein, His tag (Animal-Free)

SKU : BHP13700121

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Abbkine Scientific Co., Ltd.

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Mfr.No.	PRP2036
Description	Human CD73/NT5E protein, His tag (Animal-Free), expressed in HEK 293 Cells
Alternative Names	5' nucleotidase (CD73); 5'-NT; 5-NT; 5'-Nucleotidase; 5'-nucleotidase, ecto (CD73); CD73 antigen; CD73; E5NT; EC 3.1.3.5; ecto-5'-nucleotidase; eN; eNT; NT; NT55'-nucleotidase; NT5E; NTE; Purine 5-Prime-Nucleotidase
Features	Endotoxin:< 1 EU per ug of the protein as determined by the LAL method.
Background	CD73 (ecto-5'-nucleotidase) is a novel immunoinhibitory protein that plays a key role for tumor growth and metastasis. Its main function is to convert extracellular ATP to immunosuppressive adenosine in concert with CD39 in normal tissues to limit excessive immune response. However, tumors take advantage of the CD73-mediated adenosinergic mechanism to protect them from immune attack. In particular, inducible expression of CD73 along with other adenosinergic molecules on both cancer cells and host cells sustains immunosuppressive tumor microenvironment by affecting multiple aspects of the immune response. Owing to its multifaceted capacity to tumor promotion as an emerging immune checkpoint, CD73 is an ideal therapeutic target for cancer treatment especially in combination with conventional therapy and/or other immune checkpoint inhibitors.
Tag	CD73/NT5E
Formulation	Lyophilized from sterile PBS, pH 7.4.
Molecular Weight	59kDa
Usage	Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized human CD73 protein in the buffer which we provide not less than 100 ug/mL, which can then be further diluted to other aqueous solutions.
Accession Number	P21589
Precautions	The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Protein Length	The recombinant human CD73 protein consists of 528 amino acids and predicts a molecular mass of 59 kD.The apparent molecular mass of the human CD73 is approximately 70 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Others	Preparation Method: HEK 293 Cells

Sequence	Amino acid sequence derived from human CD73 protein (NP_002517.1, Met1-Lys547) was expressed with a polyhistidine tag at the C-terminus.

Purity	>95% as determined by SDS-PAGE
Storage	Lyophilized Human CD73/NT5E protein, His tag (Animal-Free)should be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.115% HSA or BSA). Please prevent freeze-thaw cycles.

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SKU	Supplier No.	Size	Your price	Quantity
BHP13700121	PRP2036	5 ug	$59		Add to Cart
BHP13700121	PRP2036	20 ug	$139		Add to Cart
BHP13700121	PRP2036	100 ug	$709		Add to Cart
BHP13700121	PRP2036	1 mg	$3149		Add to Cart

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