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Home / Proteins & Peptide

Human CASP8 / Caspase-8 Recombinant Protein

SKU : BHP13800054

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	R2015h
Alternative Names	Apoptotic cysteine protease,Apoptotic protease Mch-5,CAP4,FADD-homologous ICE/ced-3-like protease,FADD-like ICE,FLICE,ICE-like apoptotic protease 5,MORT1-associated ced-3 homolog,MACH,MCH5
Source	E.coli
Species	Homo Sapiens (Human)
Accession Number	Q14790
Endotoxin Level	<0.10 EU per 1 μg of the protein by the LAL method
Concentration	Reconstitution Dependent
Form	Liquid
Protein Name	Caspase-8
Entry Function	Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp- ; -AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
Mw(kda)	12.65

Subunit	Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 10 kDa (p10) subunit. Interacts with FADD, CFLAR and PEA15. Isoform 9 interacts at the endoplasmic reticulum with a complex containing BCAP31, BAP29, BCL2 and/or BCL2L1. Interacts with TNFAIP8L2 (By similarity). Interacts with CASP8AP2. Interacts with RFFL and RNF34; negatively regulate CASP8 through proteasomal degradation. Interacts with human cytomegalovirus/HHV-5 protein vICA/UL36; this interaction inhibits CASP8 activation. Interacts with NleF from pathogenic E.coli. Interacts with NOL3; decreases CASP8 activity in a mitochondria localization- and phosphorylation-dependent manner and this interaction is dissociated by calcium.
Gene Name	CASP8
Sequence	365-479aa

Purity	Greater than 95% by SDS-PAGE
Storage	Store at -20°C. (Avoid repeated freezing and thawing.)
Storage Buffer	50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)

Applications	Par, ELISA, AP, WB

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SKU	Supplier No.	Size	Your price	Quantity
BHP13800054	R2015h	50µg	$637.78		Add to Cart
BHP13800054	R2015h	100µg	$904.44		Add to Cart
BHP13800054	R2015h	200µg	$1348.89		Add to Cart
BHP13800054	R2015h	0.5mg	$1971.11		Add to Cart
BHP13800054	R2015h	1mg	$2682.22		Add to Cart
BHP13800054	R2015h	5mg	$4637.78		Add to Cart
BHP13800054	R2015h	10mg	$6148.89		Add to Cart

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