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HSP90beta, His-tag

SKU : BHP18200384

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Mfr.No.	50292
Description	Human Heat Shock Protein 90beta (GenBank Accession No. AY359878), full length with C-terminal His-tag, MW = 83 kDa, expressed in an E. coli expression system.
Background	Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for a large number of client proteins. Functional Hsp90 operates as dimer and has intrinsic ATPase activity. The Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70) and is regulated by a number of co-chaperones/accessory proteins (e.g. Hop, cdc37). Hsp90 has been shown to interact with> 100 proteins and some notable clients include kinases (e.g. Raf-1), nuclear hormone receptors (e.g. estrogen receptors), transcription factors (e.g. p53), GPCRs (e.g. CB2 receptors) and ion channels (e.g. CFTR). In humans, the Hsp90beta isoform is constitutively expressed whereas the Hsp90alpha isoforms is expressed under stress conditions. Hsp90 plays an important role in some tumor cell types by stabilising mutated oncogenic proteins. Inhibition of Hsp90beta function has been shown to play a rolein tumorigenesis and disease progression.
Immunogen Region	full length
Tag	C-terminal His-tag
Formulation	40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl,2 mM DTT, and 20% glycerol.
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	Buffer contains 0.1M HEPES, pH 7.4, 0.25M MgCl2, 0.25M KCl, 0.1M Na2MoO4, and 0.05% Triton X. Incubated Hsp90beta in a series dilution with 5 nM FITC-labeled geldanamycin for 150 minutes at room temperature. Fluorescence polarization measured at ex 470/em528. Avoid freeze/thaw cycles.
GenBank	AY359878
Mw(kda)	83 kDa

Synonyms	HSP90b, Heat Shock Protein 90b, HSP90beta, HSP90beta
Uniprot	P08238

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Milicevic Z et al., Int J Oncol. 2008 Jun;32(6):1169-78. 2. Chao C.C. et al., J Cell Biochem. 2008 Jul 1;104(4):1286-96.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200384	50292	200 ug	$434.50		Add to Cart

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