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Home / Proteins & Peptide

Histone H1, Full Length, His-tag

SKU : BHP18201515

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Mfr.No.	52043-2
Description	Human Histone H1, also known as H1F0, (GenBank Accession No. NM_005318), a.a. 2-194(end) with N-terminal His-tag, MW = 21.7 kDa, expressed in an E. coli expression system.
Background	Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation.
Immunogen Region	2-194(end)
Tag	N-terminal His-tag
Formulation	8 mM PBS pH 7.4, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, and 20% glycerol
Species	Human
Application	Useful as a substrate for histone methyltransferase and acetyltransferase assays. Ideal for screening small molecular inhibitors of histone modifying enzymes for drug discovery and HTS applications.
Notes	Avoid freeze/thaw cycles.
Amino Acid Sequence	MHHHHHHTENSTSAPAAKPKRAKASKKSTDHPKYSDMIVAAIQAEKNRAGSSRQSIQKYIKSHYKVGENADSQIKLSIKRLVTTGVLKQTKGVGASGSFRLAKSDEPKKSVAFKKTKKEIKKVATPKKASKPKKAASKAPTKKPKATPVKKAKKKLAATPKKAKKPKTVKAKPVKASKPKKAKPVKPKAKSSAKRAGKKK
GenBank	NM_005318
Mw(kda)	22 kDa

Synonyms	Histone H1, H1F0
Uniprot	P07305

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Doenecke, D., et al., J. Mol.Biol. 1986 Feb 5;187(3):461-4. 2. Vyas, P., et al., J. Biol. Chem. 2012 Apr 6;287(15):11778-87.

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SKU	Supplier No.	Size	Your price	Quantity
BHP18201515	52043-2	1 mg	$594		Add to Cart

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