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HDAC9, His-tag

SKU : BHP18200308

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BPS Bioscience

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Mfr.No.	50009
Description	Human HDAC9 , GenBank Accession No. NM_178423, a.a. 604-1066 with C-terminal His-tag, MW= 50.7 kDa, expressed in baculovirus expression system. Host cell line: Sf9 cells Specific activity: >=3000 pmol/min/ug
Immunogen Region	604-1066
Tag	C-terminal His-tag
Formulation	40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 20% glycerol, 200 mM imidazole
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	25 mM Tris HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl₂, and 0.1 mg/ml BSA, 20 uM BPS HDAC class 2a substrate (Catalog #50040), and HDAC9 (0.15 - 10 ng). Incubation condition: 30 min at 37°C, followed byHDAC developer (Catalog #50030) for 15 min at room temperature. Fluorescence intensity is measured at ex360/em460. Avoid freeze/thaw cycles.
GenBank	NM_178423
Mw(kda)	50.7 kDa

Synonyms	histone deacetylase 9, HDAC-9
Uniprot	Q9UKV0

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Han et al., (2005) J.Mol. Biol. 345, 91-102 2. Lomonte et al., (2004) J. Virol 78, 6744-6757.Application References: 1.Design, synthesis, 3D pharmacophore, QSAR, and docking studies of carboxylic acid derivatives as Histone Deacetylase inhibitors and cytotoxic agents (2014) 2. Wang, C., et al. J Med Chem. 2014 Oct 9;57(19):7999-8009. doi: 10.1021/jm500872p. In Vivo Imaging of Histone Deacetylases (HDACs) in the Central Nervous System and Major Peripheral Organs (2014) 3.The effect of various zinc binding groups on inhibition of histone deacetylases 1-11 (2014) 4.A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests (2013) 5. Fass, D.M., et al. Neuropharmacology. 2013 Jan; 64: 8196. Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity (2013) 6.FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors (2013) 7.Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group (2013)

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200308	50009	10 ug	$522.50		Add to Cart

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