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HDAC8, His-tag

SKU : BHP18200307

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BPS Bioscience

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Mfr.No.	50008
Description	Human HDAC8 , GenBank Accession No. NM_018486, full length with C-terminal His-tag, MW= 46.4 kDa, expressed in a baculovirus expression system. Host cell line: Sf9 cells Specific activity: >=300 pmol/min/ug. Unit definition: One U =1 pmol of acetyl group removed/min/ug of enzyme
Immunogen Region	full length
Tag	C-terminal His-tag
Formulation	45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 225 mMimidazole, and 10% glycerol.
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	25 mM Tris HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl₂, and 0.1 mg/ml BSA, 20 uM BPS HDAC class 2a substrate (Catalog #50040), and HDAC8 (3.1 - 200 ng). Incubation condition: 30 min at 37°C, followed byHDAC developer (Catalog #50030) for 15 min at room temperature. Fluorescence intensity is measured at ex360/em460. Avoid freeze/thaw cycles.
GenBank	NM_018486
Mw(kda)	42.4 kDa

Synonyms	histone deacetylase 8, HDAC-8
Uniprot	Q9BY41

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Lee, H. et al. Mol. Cell. Biol. 26 (14), 5259-5269 (2006). 2. Gantt,S.L. et al., Biochemistry 45 (19), 6170-6178 (2006).Application References: 1.Design, synthesis, 3D pharmacophore, QSAR, and docking studies of carboxylic acid derivatives as Histone Deacetylase inhibitors and cytotoxic agents (2014) 2.Discovery of a small molecule agonist of phosphatidylinositol 3-kinase p110alpha that reactivates latent HIV-1 (2014) 3. Wang, C., et al. J Med Chem. 2014 Oct 9;57(19):7999-8009. doi: 10.1021/jm500872p. In Vivo Imaging of Histone Deacetylases (HDACs) in the Central Nervous System and Major Peripheral Organs (2014) 4.The effect of various zinc binding groups on inhibition of histone deacetylases 1-11 (2014) 5. Meyners, C., et al. Mol Recognit. 2014 Mar;27(3):160-72. Thermodynamics of ligand binding to histone deacetylase like amidohydrolase from Bordetella/Alcaligenes (2014) 6.A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests (2013) 7. Fass, D.M., et al. Neuropharmacology. 2013 Jan; 64: 8196. Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity (2013) 8.FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors (2013) 9. Baud, MGJ, et al. ChemMedChem. 2013 Jan;8(1):149-56. doi: 10.1002/cmdc.201200450. Highly ligand efficient and selective N-2-(Thioethyl)picolinamide histone deacetylase inhibitors inspired by the natural product psammaplin A (2013) 10.Total synthesis and full histone deacetylase inhibitory profiling of Azumamides A-E as well as beta²- epi-Azumamide E and beta³-epi-Azumamide E (2013)

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200307	50008	50 ug	$506		Add to Cart

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