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HDAC7, GST-tag

SKU : BHP18201502

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BPS Bioscience

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Mfr.No.	50007-2
Description	Human HDAC7 , GenBank Accession No. AY302468, a.a. 518-end, with N-terminal GST-tag, MW= 78 kDa, expressed in baculovirus expression system. Specific activity: >=15,000 pmol/min/ug. Unit definition: One U =1 pmol of acetyl group removed/min/ug of enzyme
Immunogen Region	518-end
Tag	N-terminal GST-tag
Formulation	45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 20 mMglutathione, and 10% glycerol.
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	25 mM Tris HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl₂, and 0.1 mg/ml BSA, 20 uM BPS HDAC class 2a substrate (Catalog #50040), and HDAC7 (0.16 - 10 ng). Incubation condition: 30 min at 37°C, followed byHDAC developer (Catalog #50030) for 15 min at room temperature. Fluorescence intensity is measured at ex360/em460. Avoid freeze/thaw cycles.
GenBank	AY302468
Mw(kda)	78 kDa

Synonyms	histone deacetylase 7, HDAC-7
Uniprot	Q8WUI4

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Chakraborty S. (2006) J.Biol.Chem. 281(46):35070-80. 2. Wolfgang, F. (2001) J. Biol. Chem. 276(38): 35826-35835.Application References: 1. Abdel-Atty, M.M., et al. Bioorg Chem. 2014 Dec;57:65-82. doi: 10.1016/j.bioorg.2014.08.006. Design, synthesis, 3D pharmacophore, QSAR, and docking studies of carboxylic acid derivatives as Histone Deacetylase inhibitors and cytotoxic agents (2014) 2. Wang, C., et al. J Med Chem. 2014 Oct 9;57(19):7999-8009. doi: 10.1021/jm500872p. In Vivo Imaging of Histone Deacetylases (HDACs) in the Central Nervous System and Major Peripheral Organs (2014) 3. Schroeder, F.A., et al. PLoS One . 2013 Aug 14;8(8):e71323. doi: 10.1371/journal.pone.0071323. A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests (2013) 4. Fass, D.M., et al. Neuropharmacology. 2013 Jan; 64: 8196. Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity (2013) 5.FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors (2013)

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SKU	Supplier No.	Size	Your price	Quantity
BHP18201502	50007-2	10 ug	$484		Add to Cart

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