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Home / Proteins & Peptide

HDAC6 (H216A), GST-tag

SKU : BHP18200320

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BPS Bioscience

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Mfr.No.	50046
Description	Human HDAC6 with H216A mutation (GenBank Accession No. NM_006044), full length with N-terminal GST-tag, MW= 161 kDa, expressed in a baculovirus expression system. Host cell line: Sf9 cells Specific activity: >=380 pmol/min/ug
Immunogen Region	full length
Tag	N-terminal GST-tag
Formulation	50 mM Tris-HCl, pH 7.5, 500 mM NaCl, 50 mM KCl, 2 mM EDTA, 10% glycerol, and 2 mM DTT
Mutation	H216A
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Purification	Protein was purified by affinity chromatography and gel filtration.
Notes	25 mM Tris/HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl₂, and 0.1 mg/ml BSA, 20 uM BPS HDAC substrate 3 (Catalog #50037), and HDAC6 H216A (1.6 - 100 ng). Incubation condition: 30 min at 37°C followed byHDAC developer (Catalog #50030) for 15 min at room temperature. Fluorescence intensity is measured at ex360/em460. Avoid freeze/thaw cycles.
GenBank	NM_006044
Mw(kda)	161 kDa

Synonyms	histone deacetylase 6, HDAC6
Uniprot	Q9UBN7

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Li S. et al., Neurology. 41(2), 112-6 (2010). 2. Strausberg, R.L. et al., Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002).Application References: 1. Meyners, C., et al. Anal Biochem. 2014 Sep 1;460:39-46. doi: 10.1016/j.ab.2014.05.014. Kinetic method for the large-scale analysis of the binding mechanism of histone deacetylase inhibitors (2014) 2. Blackburn, C., et al. J Med Chem. 2013 Sep 26;56(18):7201-11. doi: 10.1021/jm400385r. Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N-hydroxybenzamide with high selectivity for the HDAC6 isoform (2013) Pavlik, C.M., et al. J Nat Prod. 2013 Nov 22;76(11):2026-33. doi: 10.1021/np400198r. Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp (2013) 4. Baud, MGJ, et al. Beilstein J Org Chem. 2013;9:81-8. doi: 10.3762/bjoc.9.11. Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors (2013)

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200320	50046	50 ug	$511.50		Add to Cart

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