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Home / Proteins & Peptide

HDAC6, FLAG-tag

SKU : BHP18200323

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BPS Bioscience

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Mfr.No.	50056
Description	Human HDAC6 (GenBank Accession No. NM_006044), full length with C-terminal FLAG-tag, MW= 132 kDa, expressed in baculovirus expression system. Host cell line: Sf9 cells Specific activity: >=146 pmol/min/ug. Unit definition: One U =1 pmol of acetyl group removed/min/ug of enzyme
Immunogen Region	full length
Tag	C-terminal FLAG-tag
Formulation	40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 80 ng/ul FLAG peptide,and 20% glycerol.
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Purification	Protein was purified by affinity chromatography and gel filtration.
Notes	25 mM Tris/HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl₂, and 0.1 mg/ml BSA, 30 uM BPS HDAC substrate (Catalog #50037), and HDAC6. Incubation condition: 30 min at 37°C followed by HDAC developer (Catalog #50030) for 15 min at room temperature. Fluorescence intensity is measured at ex360/em460. Avoid freeze/thaw cycles.
GenBank	NM_006044
Mw(kda)	132 kDa

Synonyms	histone deacetylase 6, HDAC-6
Uniprot	Q9UBN7

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	Strausberg, R.L. et al., Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002). Application References: 1. Meyners, C., et al. Anal Biochem. 2014 Sep 1;460:39-46. doi: 10.1016/j.ab.2014.05.014. Kinetic method for the large-scale analysis of the binding mechanism of histone deacetylase inhibitors (2014) 2. Blackburn, C., et al. J Med Chem. 2013 Sep 26;56(18):7201-11. doi: 10.1021/jm400385r. Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N-hydroxybenzamide with high selectivity for the HDAC6 isoform (2013) Pavlik, C.M., et al. J Nat Prod. 2013 Nov 22;76(11):2026-33. doi: 10.1021/np400198r. Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp (2013) 4. Baud, MGJ, et al. Beilstein J Org Chem. 2013;9:81-8. doi: 10.3762/bjoc.9.11. Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors (2013)

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200323	50056	50 ug	$544.50		Add to Cart

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