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Home / Proteins & Peptide

HDAC5 (full length), GST-tag

SKU : BHP18200319

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BPS Bioscience

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Mfr.No.	50045
Description	Human HDAC5 , GenBank Accession No. NM_005474, full length with N-terminal GST-tag, MW= 150 kDa, expressed in baculovirus expression system. Host cell line: Sf9 cells Specific activity: >=2500 pmol/min/ug. Unit definition: One U =1 pmol of acetyl group removed/min/ug of enzyme
Immunogen Region	full length
Tag	N-terminal GST-tag
Formulation	40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 16 mM glutathione, 20% glycerol
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	25 mM Tris HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl₂, and 0.1 mg/ml BSA, 20 uM BPS substrate(Catalog number 50040), and 0.8-50 ng/ul HDAC5. Incubation condition: 30 min at 37°C followed byHDAC developer (Catalog #50030) for 15 min at room temperature. Fluorescence intensity is measured at ex360/em460. Avoid freeze/thaw cycles.
GenBank	NM_005474
Mw(kda)	150 kDa

Synonyms	histone deacetylase 5, HDAC-5
Uniprot	Q9UQL6

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Spiegelberg, B.D. and Hamm, H.E. (2005) J. Biol. Chem. 280, 41769-41776 2. Waltregny et al., (2004) J. Neural Transm. 48, 273-290.Application References: 1. In Vivo Imaging of Histone Deacetylases (HDACs) in the Central Nervous System and Major Peripheral Organs (2014) 2. A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests (2013) 3. Fass, D.M., et al. Neuropharmacology. 2013 Jan; 64: 8196. Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity (2013) 4.Total synthesis and full histone deacetylase inhibitory profiling of Azumamides A-E as well as beta²- epi-Azumamide E and beta³-epi-Azumamide E (2013)

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200319	50045	5 ug	$539		Add to Cart

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