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Home / Proteins & Peptide

HDAC5, Catalytic Domain, His-tag

SKU : BHP18200305

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Mfr.No.	50005
Description	Human HDAC5 catalytic domain , GenBank Accession No. NM_005474, a.a. 656-1122 (end) with C-terminal His-tag, MW= 51 kDa, expressed in baculovirus expression system. Host cell line: Sf9 cells Specific activity: >=1000 pmol/min/ug. Unit definition: One U =1 pmol of acetyl group removed/min/ug of enzyme
Immunogen Region	656-1122 (end)
Tag	C-terminal His-tag
Formulation	45 mM Tris-HCl, pH 8.0, 124mM NaCl, 2.4 mM KCl, 225 imidazole, and10% glycerol.
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	25 mM Tris HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl₂, and 0.1 mg/ml BSA, 30 uM BPS HDAC class 2a substrate , BPS Catalog number 50040, and HDAC5. Incubation condition: 30 min at 30°C, followed by HDAC developer (Catalog #50030) for 15 min at room temperature. Fluorescence intensity is measured at ex360/em460. Avoid freeze/thaw cycles.
GenBank	NM_005474
Mw(kda)	51 kDa

Synonyms	histone deacetylase 5, HDAC-5
Uniprot	Q9UQL6

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Spiegelberg, B.D. and Hamm, H.E. (2005) J. Biol. Chem. 280, 41769-41776 2. Waltregny et al., (2004) J. Neural Transm. 48, 273-290.Application References: 1.Design, synthesis, 3D pharmacophore, QSAR, and docking studies of carboxylic acid derivatives as Histone Deacetylase inhibitors and cytotoxic agents (2014) 2.Identification and characterization of small-molecule inhibitors of lysine acetyltransferases (2014) 3. Wang, C., et al. J Med Chem. 2014 Oct 9;57(19):7999-8009. doi: 10.1021/jm500872p. In Vivo Imaging of Histone Deacetylases (HDACs) in the Central Nervous System and Major Peripheral Organs (2014) 4.The effect of various zinc binding groups on inhibition of histone deacetylases 1-11 (2014) 5.A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests (2013) 6. Fass, D.M., et al. Neuropharmacology. 2013 Jan; 64: 8196. Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity (2013) 7.FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors (2013)

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200305	50005	10 ug	$484		Add to Cart

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