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Home / Proteins & Peptide

HB-EGF, Mouse

SKU : BHP18500158

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iXCells Biotechnologies

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Mfr.No.	IX02943, IX02943-1, IX02943-10, IX02943-50
Description	Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins. HB-EGF-like growth factor is synthesized as a membrane-anchored mitogenic and chemotactic glycoprotein. An epidermal growth factor produced by monocytes and macrophages, due to an affinity for heparin is termed HB-EGF. It has been shown to play a role in wound healing, cardiac hypertrophy and heart development and function. The transmembrane form of HB-EGF is the unique receptor for diptheria toxin and functions in juxtacrine signaling in cells. Both forms of HB-EGF participate in normal physiological processes and in pathological processes including tumor progression and metastasis, organ hyperplasia, and atherosclerotic disease. HB-EGF can bind two locations on cell surfaces, heparan sulfate proteoglycans and EGF-receptor effecting cell to cell interactions.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at <= -20 °C. Further dilutions should be made in appropriate buffered solutions.
Formulation	Lyophilized from a 0.2 um filtered concentrated solution in 10 mM PB, 500 mM NaCl, pH7.4.
Molecular Weight	Approximately 9.8 kDa, a single non-glycosylated polypeptide chain containing 86 amino acids.
Physical Appearance	Sterile Filtered White lyophilized (freeze-dried) powder.
Source	E. coli
Host	Mouse
Endotoxin Level	Less than 1 EU/ug of rMuHB-EGF as determined by LAL method.
Bioactivity	Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 1 ng/ml, corresponding to a specific activity of 1.0 x 106 IU/mg.

Synonyms	Heparin Binding EGF-like growth factor, HBEGF, Diphtheria toxin receptor, DTR
Sequence	DLEGTDLNLF KVAFSSKPQG LATPSKERNG KKKKKGKGLGKKRDPCLRKY?KDYCIHGECR YLQEFRTPSC KCLPGYHGHR CHGLTL

Purity	97 % by SDS-PAGE and HPLC analyses.
Storage	This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500158-1	IX02943-1	1mg	$1310		Add to Cart
BHP18500158-2	IX02943-10	10ug	$82		Add to Cart
BHP18500158-3	IX02943-50	50ug	$199		Add to Cart

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