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Home / Proteins & Peptide

HB-EGF, Human

SKU : BHP18500432

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Mfr.No.	IX03291, IX03291-1, IX03291-10, IX03291-50
Description	Proheparin-binding EGF-like growth factor (HB-EGF), also known as DTR, DTS and HEGFL, is a member of the EGF family of mitogens. It is expressed in macrophages, monocytes, endothelial cells and muscle cells. HB-EGF signals through the EGF receptor to stimulate the proliferation of smooth muscle cells, epithelial cells and keratinocytes. Compared to EGF, HB-EGF binds to the EGF receptor with a higher affinity and has been shown to bemore mitogenic, likely due to its ability to bind to heparin and heparin sulfate proteoglycans. HB-EGF has also been reported to act as a diphtheria toxin receptor, mediating endocytosis of the bound toxin. Heparin-binding EGF-like growth factor has been shown to interact with NRD1, Zinc finger and BTB domain-containing protein 16 and BAG1.Recombinant Human HB-EGF produced in E. coli cells is a polypeptide chain containing 86 amino acids. A fully biologically active molecule, rhHB-EGF has a molecular mass of 14 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	14 kDa, observed by reducing SDS-PAGE.
Source	E. coli
Accession Number	Q99075
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	ED50 0.75ng/ml, measured in a cell proliferation assay using 3T3 cells.

Synonyms	Heparin Binding EGF-like growth factor, HBEGF, Diphtheria toxin receptor, DTR
Sequence	Asp63-Leu148 (Accession #:Q99075)

Purity	95% as analyzed by SDS-PAGE.
Storage	Lyophilized recombinant Human Proheparin-binding EGF-like Growth Factor (HB-EGF), remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, human HB-EGF should be stable up to 1 week at 4°C or up to 3 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500432-1	IX03291-1	1mg	$937		Add to Cart
BHP18500432-2	IX03291-10	10ug	$50		Add to Cart
BHP18500432-3	IX03291-50	50ug	$113		Add to Cart

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