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Home / Proteins & Peptide

HB-EGF, Human

SKU : BHP18500303

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iXCells Biotechnologies

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Mfr.No.	IX03142, IX03142-1, IX03142-25, IX03142-5
Description	Proheparin-binding EGF-like growth factor (HB-EGF), also known as DTR, DTS and HEGFL, is a member of the EGF family of mitogens. It is expressed in macrophages, monocytes, endothelial cells and muscle cells. HB-EGF signals through the EGF receptor to stimulate the proliferation of smooth muscle cells, epithelial cells and keratinocytes. Compared to EGF, HB-EGF binds the EGF receptor with higher affinity and is thus more mitogenic, probably due to its ability to bind to heparin and heparin sulfate proteoglycans. HB-EGF has been reported to act as a diphtheria toxin receptor, mediating endocytosis of the bound toxin.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	12-14 kDa, observed by reducing SDS-PAGE.
Source	CHO
Host	Human
Accession Number	Q99075
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	ED50 0.5 ng/ml, measured in a cell proliferation assay using 3T3 cells.

Synonyms	DTR, DTS, HEGFL
Sequence	DLQEADLDLL RVTLSSKPQA LATPNKEEHG KRKKKGKGLGKKRDPCLRKY KDFCIHGECK YVKELRAPSC ICHPGYHGERCHGLSL

Purity	95% as analyzed by SDS-PAGE and HPLC.
Storage	Lyophilized recombinant Human HB-EGF remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human HB-EGF should be stable up to 1 week at 4°C or up to 2 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500303-1	IX03142-1	1mg	$937		Add to Cart
BHP18500303-2	IX03142-25	25ug	$95		Add to Cart
BHP18500303-3	IX03142-5	5ug	$32		Add to Cart

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