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Home / Proteins & Peptide

GRO beta/CXCL2, Human

SKU : BHP18500443

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iXCells Biotechnologies

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Mfr.No.	IX03304, IX03304-1, IX03304-25, IX03304-5
Description	Human GRO-alpha, GRO-beta (MIP-2alpha), and GRO-gamma (MIP-2beta) are products of three distinct, nonallelichuman genes. GRO-beta and GRO-gamma share 90% and 86% amino acid sequence homology, respectively, with GROalpha. All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors.GRO expression is inducible by serum or PDGF and/or by a variety of inflammatory mediators, such as IL-1 and TNF, in monocytes, fibroblasts, melanocytes and epithelial cells. In certain tumor cell lines, GRO is expressed constitutively.Similar to other alpha chemokines, the three GRO proteins are potent neutrophil attractants and activators. In addition, these chemokines are also active toward basophils.Recombinant Human GRO beta/CXCL2 produced in E.coli is a single non-glycosylated polypeptide chain containing 74 amino acids. A fully biologically active molecule, rhGRO beta/CXCL2 has a molecular mass of 8.0 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	8.0 kDa, observed by reducing SDS-PAGE.
Source	E. coli
Accession Number	P19875
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	The EC50 value of human GRO beta on Ca2+ mobilization assay in CHO-K1/Galpha15/hCXCR2 cells (human Galpha15 and human CXCR2 stably expressed in CHO-K1 cells) is less than 200 ng/ml.

Synonyms	Growth Regulated Protein/Melanoma Growth Stimulatory Activity (MGSA ?), CXCL2, MIP-2?, GRO2
Sequence	Ala35-Asn107 (Accession #:P19875)

Purity	95% as analyzed by SDS-PAGE.
Storage	Lyophilized recombinant Human GRO beta/CXCL2 remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human GRO beta/CXCL2 should be stable up to 1 week at 4°C or up to 3 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500443-1	IX03304-1	1mg	$1686		Add to Cart
BHP18500443-2	IX03304-25	25ug	$220		Add to Cart
BHP18500443-3	IX03304-5	5ug	$63		Add to Cart

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