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Home / Proteins & Peptide

GM-CSF, Human (P. pastoris-expressed)

SKU : BHP18500013

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iXCells Biotechnologies

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Mfr.No.	IX02190, IX02190-1, IX02190-10, IX02190-50
Description	Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts) in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, GM-CSF is also a growth factor for erythroid, megakaryocyte and eosinophil progenitors. On mature hematopoietic, monocytes/ macrophages and eosinophils. GM-CSF has also been reported to have a functional role on non-hematopoitic cells. It can induce human endothelial cells to migrate and proliferate. Additionally, GM-CSF can also stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma and adenocarcinoma cell lines.iXCells Human Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) (Sargramostim), is a single, glycosylated polypeptide chain containing 127 amino acids and having a molecular mass of about 24,000-35,000 Da, as shown in SDS-PAGE. It differs from natural human GM-CSF by a substitution of leucine at position 23 (R to L), and the carbohydrate moiety may be different from the native protein.
Reconstitution	It is recommended to reconstitute the lyophilized Sargramostim in sterile 18 Momega-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Formulation	The protein was lyophilized after extensive dialysis against 10mM Tris-HCl, pH8.5, 4% Mannitol, 1% Sucrose buffer.
Molecular Weight	24,000-35,000 Da
Source	P. pastoris
Specificity	The ED50 as determined by the dose-dependant stimulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line) is less than 0.2 ng/ml, corresponding to a specific activity of 5.0x106 IU/ mg.
Host	Human
Endotoxin Level	Less than 0.1 ng/ug (1 EU/ug) of sargramostim

Synonyms	rHu GM-CSF, Sargramostim, Recombinant Human GM-CSF, Sargramostim;
Sequence	The sequence of thefirst five N-terminal aminoacids was determined andwas found to beAla-Pro-Ala-Arg-Ser.

Purity	The purity level of iXCells Recombinant Human GM-CSF is greater than 95.0%, as determined by the following methods: (a) RP-HPLC anaylsis(b) Reducing and non-reducing SDS-PAGE silver-stained gel analysis
Storage	Although lyophilized iXCells Sargramostim can remain stable at room temperature for three weeks, it is best stored desiccated below -18°C. Upon reconstitution Sargramostim should be stored at 4°C between 2-7 days and for future use below -18°C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500013-1	IX02190-1	1mg	$2808		Add to Cart
BHP18500013-2	IX02190-10	10ug	$120		Add to Cart
BHP18500013-3	IX02190-50	50ug	$406		Add to Cart

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