Human secreted GITR, also known as Glucocorticoid-induced TNFR-Related Protein, Tumor Necrosis Factor Receptor Superfamily member 18, TNFRSF18, Activation-Inducible TNFR Family Receptor, AITR, and CD357, GenBank Accession No. NM_004195, a.a. 26-161 expressed in a HEK293 cell expression system, fused at the C-terminus to the Fc portion of human IgG1, and enzymatically biotin-labeled using Avi-tag technology. MW = 43 kDa (monomer). This protein runs at a higher MW by SDS-PAGE due to glycosylation.
Immunogen Region
26-161
Tag
C-terminal Fc fusion (Human IgG1)
Formulation
8 mM Phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Species
Human
Notes
GITR-biotin binding to GITRL was confirmed using the GITRL:GITR(Biotinylated) Inhibitor Screening Assay Kit (BPS Cat. #72061).
Avoid freeze/thaw cycles.
GenBank
NM_004195
Mw(kda)
43 kDa
Synonyms
Glucocorticoid-induced TNFR-Related Protein, Tumor Necrosis Factor Receptor Superfamily member 18, TNFRSF18, Activation-Inducible TNFR Family Receptor, AITR, and CD357
Uniprot
Q9Y5U5
Shipping Temperature
-80°C (dry ice)
Format
Aqueous buffer solution
Storage
At least 6 months at -80°C.
Reference
1. Shimizu, J., et al., Nat. Immunol. 2002; 3: 135-142.2. Ko, K., et al., J. Exp. Med. 2005; 202(7): 885-891.