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Home / Proteins & Peptide

FGF-acidic, Mouse

SKU : BHP18500235

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iXCells Biotechnologies

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Mfr.No.	IX03049, IX03049-1, IX03049-10, IX03049-50
Description	Fibroblast Growth Factor- acidic (FGF-acidic) is a mitogen targeting at the endothelial cells, and belongs to the heparin binding FGF family, which contains 22 members. FGF-acidic binds to the receptor family FGFR1-4 in vivo with the assistance of heparin. However, along with FGF -basic, FGF-acidic lacks the signal peptide segment, and thus is not secreted via endoplasmic reticulum (ER) and Golgi bodies. Studies have shown that FGF-acidic is highly regulated, and it is a direct angiogenesis factor. If unregulated, angiogenesis could contribute to several diseases including arthritis, diabetes, ocular neovascularization, and especially tumors. Therefore, FGF-acidic is treated as a potential oncogene, and its overexpression is correlated tightly with several cancers. Recombinant mouse Fibroblast Growth Factor- acidic (rmFGF-acidic) produced in E. coli is a single non-glycosylated polypeptide chain containing 140 amino acids. A fully biologically active molecule, rmFGF-acidic has a molecular mass of 15.8 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques.
Reconstitution	Reconstituted in ddH2O at 100 ug/mL.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	15.8 kDa, observed by reducing SDS-PAGE.
Source	E. coli
Host	Mouse
Accession Number	P61148
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	ED50 0.4 ng/mL, measured by a cell proliferation assay using 3T3 cells in the presence of 10 ug/mL heparin, corresponding to a specific activity of 2.5x 106 units/mg.

Synonyms	Fibroblast Growth Factor-acidic, FGF-1, HBGF-1, ECGF-beta
Sequence	FNLPLGNYKK PKLLYCSNGG HFLRILPDGT VDGTRDRSDQHIQLQLSAES AGEVYIKGTE TGQYLAMDTE GLLYGSQTPNEECLFLERLE ENHYNTYTSK KHAEKNWFVG LKKNGSCKRGPRTHYGQKAI LFLPLPVSSD

Purity	95% by SDS-PAGE and HPLC analyses.
Storage	Lyophilized recombinant mouse Fibroblast Growth Factor- acidic (rmFGF-acidic) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rmFGF-acidic should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500235-1	IX03049-1	1mg	$781		Add to Cart
BHP18500235-2	IX03049-10	10ug	$50		Add to Cart
BHP18500235-3	IX03049-50	50ug	$107		Add to Cart

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