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Home / Proteins & Peptide

FcRn (FCGRT/B2M) Blocker

SKU : BHP18201463

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BPS Bioscience

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Mfr.No.	101468-2
Description	The FcRn (FCGRT/B2M) blocker (Fc-Tag) is a purified human protein corresponding to the Fc region of an antibody which has been engineered to bind to human neonatal Fc Receptor for IgG (FcRn; FCGRT/B2M) with high affinity. This antibody has been tested for specific binding to human FcRn (Biohippo #71283) and it blocks the binding of FcRn with immunoglobulins G. host species: human Host species: human Host cell line: HEK293
Formulation	8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Species	Human
Application	This product is for research use only. It is not suitable for human diagnostic or therapeutic use.
Purification	Protein A affinity
Notes	Assay 1. A 96-well plate was coated overnight at 4°C with 50 ul/well of the FcRn blocker at a concentration of 2 ug/ml, diluted in PBS. The plate was washed 3 times with Immuno Buffer 1 (Biohippo #79311) and blocked with 100 ul of Blocking Buffer 6 for an hour at room temperature. A serial dilution of biotinylated FcRn protein (Biohippo #71283) prepared in Blocking Buffer 6 was added for 30 minutes. After 3 washes, the plate was incubated with Streptavidin-HRP followed by more washes and addition of a colorimetric HRP substrate. After quenching, color intensity was measured at 450 nm.Assay 2. The effect of FcRn (FCGRT/B2M) Blocker was assessed using the Fc(IgG1):FcRn Inhibitor Screening colorimetric kit (Biohippo #78501) using the following conditions: Fc(IgG1) protein at 2 ug/ml, diluted in PBS, serial dilution of FcRn Blocker prepared in blocking buffer, and 1.5 ug/ml of FcRn-Biotin. Avoid freeze/thaw cycles.
Mw(kda)	51.2 kDa (homo-dimer); Chain: 25.6 kDa

Synonyms	IgG receptor FcRn large subunit p51, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor, FCGRT, FCRN
Uniprot	P55899

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Purity	>=90%
Storage	At least 12 months at -80°C.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18201463	101468-2	100 ug	$561		Add to Cart

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