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Home / Proteins & Peptide

FALZ (BPTF), His-tag

SKU : BHP18200104

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Mfr.No.	31131
Description	Human Fetal Alzheimer Antigen (FALZ), lso known as Fetal Alz-50 Clone 1 Protein or bromodomain PHD finger transcription factor (BPTF), GenBank Accession No. NM_182641, a.a. 2791-2911 corresponding to single bromodomain, with N-terminal His-tag, MW=15.2 kDa, expressed in an E. coli expression system.
Background	FALZ is a bromodomain-containing protein that is the histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on Lys4 (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. High levels of FALZ were detected in fetal brain and in patients with neurodegenerative diseases.
Immunogen Region	2791-2911
Tag	N-terminal His-tag
Formulation	45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 225 mM imidazole, 3 mM DTT, and 10% glycerol.
Species	Human
Application	Useful for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling.
Notes	Avoid freeze/thaw cycles.
GenBank	NM_182641
Mw(kda)	15.2 kDa

Synonyms	Bromodomain and PHD finger containing 4, FALZ, BPTF, fetal Alzheimer antigen
Uniprot	Q12830

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Buganim, Y., et al.,Structure. PLoS One. 2010;11;5(3):e9657. 2. Ruthenburg, A.J., et al., Cell. 2011;145(5):692-706.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200104	31131	100 ug	$335.50		Add to Cart

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