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Home / Proteins & Peptide

EZH2 (non-complexed), His-GST-tags

SKU : BHP18200373

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Mfr.No.	50279
Background	EZH2 is the catalytic subunit of the PRC2/EED-EZH2 complex, which methylates Lys9 (H3K9me) and Lys27 (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate Lys27 of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4.
Immunogen Region	2-end
Tag	N-terminal His-GST-tags
Description	Human EZH2 (GenBank Accession No. NM_004456), a.a. 2-end with N-terminal His-GST-tag, MW= 114 kDa, expressed in a Sf9 baculovirus expression system. This protein is inactive alone, although it is functional if combined with other proteins in the complex. Host cell line: Sf9 cells
Formulation	40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 16 mM glutathione, 3 mM DTT, and 20% glycerol.
Species	Human
Application	Useful for Western blot analysis and to investigate protein-protein interactions in the EZH2 complex.
Notes	Avoid freeze/thaw cycles.
GenBank	NM_004456
Mw(kda)	114 kDa

Synonyms	KTM6A, EZH2, PRC2, Enhancer Of Zeste Homolog 2, EZH, KMT6
Uniprot	Q15910

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Varambally, S. et al. Science 322 (5908), 1695- 1699 (2008). 2. Rakotobe, D. et al., Virol. J. 5, 32 (2008).

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200373	50279	20 ug	$539		Add to Cart

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