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EPHA4, GST-tag

SKU : BHP18200187

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Mfr.No.	40193
Description	Human EPHA4 (Ephrin Receptor A4), also known as TYRO1, SEK, and HEK8, GenBank Accession No. NM_004438, a.a. 610-887, with N-terminal GST-tag, MW ~58 kDa, expressed in Sf9 insect cells via a baculovirus expression system. Host cell line: Sf9 cells Specific activity: 61 pmol/min/ug
Background	EPHA4 also known as EPH receptor A4, belongs to the ephrin receptor subfamily of protein-tyrosine kinases which have been implicated in mediating developmental events, particularly in the nervous system (1). The EPHA4 ligand ephrin-A3 is localized to the astrocytic processes that envelop the spine. Activation of EPHA4 by ephrin-A3 induces spinal retraction and reduces spine density and inhibits the interaction distorted spine shape and organization. EPHA4-null mice possess defects in the corticospinal tract and anterior commissure indicating a model in which an ephrin ligand on the axons senses EPHA4 on spinal cord cells surrounding the corticospinal tract (2).
Immunogen Region	610-887
Tag	N-terminal GST-tag
Formulation	50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Species	Human
Application	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Notes	Assay was done in Kinase buffer containing 0.2 mM DTT using Poly-(Glu4:Tyr)-biotin substrate (0.2 mg/ml) and 20 uM ATP. Reaction was done at 30°C for 40 min. Amount of ATP transferred was calculated using Kinase-Glo reagent (Promega). Avoid freeze/thaw cycles.
GenBank	NM_004438
Mw(kda)	58 kDa

Synonyms	SEK, HEK8, TYRO1
Uniprot	P54764

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Purity	>=90%
Storage	At least 6 months at -80°C.

Reference	1. Flanagan, J.G. et al: The ephrins and Eph receptors in neural development.". Annu. Rev. Neurosci. 1998;21: 309-45. 2. Dottori, M. et al: EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract. Proc. Nat. Acad. Sci. 95: 13248-13253, 1998.

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200187	40193	10 ug	$390.50		Add to Cart

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