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Home / Proteins & Peptide

Endostatin, Human

SKU : BHP18500018

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iXCells Biotechnologies

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Mfr.No.	IX02533, IX02533-100, IX02533-20
Description	Endostatin is a cleaved product of the carboxyl-terminal domain of collagen XVIII. It functions as an anti-angiogenic cytokine that is expressed in various organs especially with high levels in liver, lung, and kidney. Endostatin inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF-basic. Recombinant Endostatin expressed in yeast, whichcauses G1 arrest of endothelial cells. Endostatin treatment results in apoptosis of HUVE and HMVE cells. Recombinant human Endostatin is a 20.2 kDa protein consisting of 184 amino acid residues.
Formulation	The sterile filtered solution was lyophilized with 17 mM citric-phosphate buffer, pH 6.2.
Source	P. pastoris
Host	Human
Endotoxin Level	Endotoxin level is less than 0.1 ng per ug (1EU/ug) of Endostatin.
Bioactivity	Determined by Endothelial Cell Tube Formation. The cells treated with 10ug/ml Endostatin showed significant anti-angiogenesis effect.

Synonyms	Endostatin;
Sequence	AHSHRDFQPV LHLVALNSPL SGGMRGIRGA DFQCFQQARAVGLAGTFRAF LSSRLQDLYS IVRRADRAAV PIVNLKDELLFPSWEALFSG SEGPLKPGAR IFSFDGKDVL RHPTWPQKSVWHGSDPNGRR LTESYCETWR TEAPSATGQA SSLLGGRLLGQSAASCHHAY IVLCIENSFM TASK

Purity	Greater than 97% by SDS-PAGE
Storage	The lyophilized Endostatin is stable for a few weeks at room temperature, but best stored at -20°C. For the first use, reconstitute in water, aliquot and store at -20°C to avoid multiple freeze-thaws.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500018-1	IX02533-100	100ug	$120		Add to Cart
BHP18500018-2	IX02533-20	20ug	$49		Add to Cart

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