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Home / Proteins & Peptide

ENA78/CXCL5(9-78 a.a.), Human

SKU : BHP18500412

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iXCells Biotechnologies

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Mfr.No.	IX03271, IX03271-1, IX03271-25, IX03271-5
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Description	Epithelial cellderived neutrophilactivating peptide (ENA78) also known as C-X-C motif chemokine 5(CXCL5), is a small cytokine belonging to the CXC chemokine family. It is produced following stimulation of cells with the inflammatory cytokines interleukin-1 or tumor necrosis factor-alpha. Expression of CXCL5 has also been observed in eosinophils, and can be inhibited with the type II interferon, IFN-gamma. This chemokine stimulates the chemotaxis of neutrophils possessing angiogenic properties Full length CXCL5 (78 a.a.) is cleaved at the Nterminal end by cathepsin G and chymotrypsin to ENA-74 (74 a.a.) and ENA-70 (70a.a.), with the shortened forms showing increased potency relative to full length CXCL5. CXCL5can signal through the CXCR2 receptor.Recombinant human ENA-78/CXCL5 (9-78a.a.) produced in E.coli is a single non-glycosylated polypeptide chain containing 70 amino acids. A fully biologically active molecule, rhENA-78/CXCL5 (9-78a.a.) has a molecular mass of 7.7 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	7.7 kDa, observed by reducing SDS-PAGE.
Source	E. coli
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	The EC50 value of human ENA78/CXCL5 (9-78 a.a.) on Ca2+ mobilization assay in CHO-K1/G?15/hCXCR2 cells (human G?15 and human CXCR2 stably expressed in CHO-K1 cells) is less than 50 ng/ml.

Synonyms	Epithelial Neutrophil Activating Peptide-78, CXCL5,ENA-78
Sequence	Arg45-Asn114 (Accession #: P42830)

Purity	95% as analyzed by SDS-PAGE.
Storage	Lyophilized recombinant human ENA78/CXCL5 (9-78a.a.) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, human ENA78/CXCL5(9-78) should be stable up to 1 week at 4°C or up to 2 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500412-1	IX03271-1	1mg	$1686		Add to Cart
BHP18500412-2	IX03271-25	25ug	$120		Add to Cart
BHP18500412-3	IX03271-5	5ug	$50		Add to Cart

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