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Home / Proteins & Peptide

DNA Polymerase gamma (POLG), His-FLAG-tag

SKU : BHP18200019

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Mfr.No.	21001
Description	Human DNA polymerase gamma (gamma), also known as Pol gamma and POLG (GenBank Accession No. NM_002693), a.a. 2-1239 (end), with N-terminal His-tag and N-terminal FLAG-tag, MW=141 kDa, expressed in a baculovirus infected Sf9 cell expression system. host species: insect Host species: insect Host cell line: Sf9 cells
Background	POLG is the catalytic subunit of the mitochondrial DNA polymerase. The catalytic subunit contains three enzymatic activities, a DNA polymerase activity, a 3'-5' exonuclease activity that proofreads misincorporated nucleotides, and a 5'-dRP lyase activity required for base excision repair. Mutations in the POLG gene are associated with several mitochondrial diseases, including Alpers' disease, ataxia-neuropathy disorders, and dominant and recessive forms of progressive external ophthalmoplegia.
Immunogen Region	2-1239 (end)
Tag	N-terminal His-FLAG-tag
Formulation	40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 80 ug/ml FLAG peptide, 0.04% Tween-20, and 20% glycerol.
Species	Human
Application	Useful for DNA synthesis and DNA repair, as an antigen for Western blotting, and for inhibitor screening.
Notes	Avoid freeze/thaw cycles.
GenBank	NM_002693
Mw(kda)	141 kDa

Synonyms	DNA polymerase gamma, Pol gamma, POLG
Uniprot	P54098

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Ropp, P.A., and Copeland, W.C., Genomics 1996;36(3):449-458. 2. Lestienne, P., Biochem. Biophys. Res. Comm. 1987;146(3): 1146-1153.Application Reference(s): La, J., et al. Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):6979-84. Identification of mechanistically distinct inhibitors of HIV-1 reverse transcriptase through fragment screening (2015)

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18200019	21001	100 ug	$385		Add to Cart

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