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Home / Proteins & Peptide

DNA Polymerase beta (POLB), His-tag

SKU : BHP18201497

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Mfr.No.	21000-1
Description	Human DNA polymerase beta (beta), also known as Pol beta and POLB (GenBank Accession No. NM_002690), a.a. 2-335 (end), with N-terminal His-tag, MW=39 kDa, expressed in an E. coli cell expression system.
Background	DNA polymerase involved in base excision and repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. The protein is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage.
Immunogen Region	2-335 (end)
Tag	N-terminal His-tag
Formulation	40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 250 mM imidazole, 0.04% Tween-20, and 20% glycerol.
Species	Human
Application	Useful for DNA synthesis and DNA repair, as an antigen for Western blotting, and for inhibitor screening.
Notes	Avoid freeze/thaw cycles.
GenBank	NM_002690
Mw(kda)	39 kDa

Synonyms	DNA polymerase beta, Pol beta and POLB
Uniprot	P06746

Shipping Temperature	-80°C (dry ice)
Format	Aqueous buffer solution
Storage	At least 6 months at -80°C.

Reference	1. Yamtich, J., et al., PLoS Genet. 2012,8(11): E1003052. 2. Wang, K., et al., Cancer Res. 1992,52(17): 4824-4827.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP18201497	21000-1	100 ug	$385		Add to Cart

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